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浠缁浠浠璇锛借

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琛缁锛剧ユ锛medlive.cn锛

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灏卞ㄨ涓跺锛涓涓婚㈠璧蜂磋叮

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浠浜姣涓肩绌惰戒浜ヨ

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寮浜锛繁笺

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婚剧ユ浜缁锛

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娉ㄩ锛

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[1] 绛. 璇卞娉搴ㄧ[J]. 涓娑插蹇, 1994, 15(2): 105107.

[2] 藉己, 浠茶豹. 缁寸查歌х虹跺藉绛[J]. 涓藉楠琛娑插蹇, 1995, 0(3): 245249.

[3] . 寮灞峰娌荤借涓村哄剁绌[J]. 涓娑插蹇, 1996, 17(2): 5757.

[4] . 浼[M]. 涓娴蜂氦澶у虹绀, 2015.

[5] 藉己, 妗. 涓姘у浜峰ユф╁辜绮缁х借缁搴绌[J]. 涓诲蹇, 1997, 77(7): 509512.

[6] CHEN G-Q绛. Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): I. As2O3 Exerts Dose-Dependent Dual Effects on APL Cells[J]. Blood, 1997, 89(9): 33453353.

[7] 骞崇. 涓姘у浜锋跨やㄧ绌[J]. 涓戒腑蹇, 1999, 24(3): 174175.

[8] SHEN Z-X绛. Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients[J]. Blood, 1997, 89(9): 33543360.