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哄锛绉腑

朵锛涓甫涓绌舵 寰ц

讹涓界瀛㈣绠虹缁淇℃腑蹇

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姘娓╀澶╁ぉ楂锛浣娌℃帮繁浼间村缂姘涓锛绋寰逛椤哄浜灏变澶уㄨ跺杩纰ㄤ绁锛绌惰〃娓╁害楂锛浜虹纰句

锛剧ヨ缁锛

浠涔纰锛

纰涓村琛ㄧ浠ユ楂娑ㄦ浣戒负涓伙浼存缁村告杩缂锛绮剧杩ㄦу村躲

韬舵讹ｈ蹇澧楂涓澶澧涓哥О锛浠ュ撮锛婵广婵瓒蹇挎锛涓ラ浠ュ虹涓澧涓濡炽骞昏绛绮剧躲

韬舵锛剧ヨ缁锛

舵剁浜哄涓浣炽笺蹇т激版茶缁锛楂翠璧锋ワ磋叮涓уけ锛璇浠蜂涓ラ虹瑙蹇靛琛涓猴奸澶杞荤寰

舵锛剧ヨ缁锛

浠涔瀵艰翠汉绫绘ｆ纰

绌跺锛缃绁搁缁璐ㄥ浣哄锛朵腑5-缇茶猴5-hydroxytryptamine锛 5-HT锛ぇ涓绉瑕绁缁璐跺ㄥぇ璐ㄥ绁缁瑙朵哄楂锛瀹戒浣夸汉浜х涓绉缁涔奖颁汉绫诲ぇ娲诲ㄧ姣釜归杩涔澶у扮簿绁绉╅芥ㄤ5-缇茶虹规

5-缇茶猴剧ヨ缁锛

5-缇茶烘辩璐ㄨ5-缇茶鸿浆杩浣锛5-hydroxytryptamine transporter,5-HTT锛ヨ锛5-缇茶鸿浆杩浣绉瀵5-缇茶烘楂搴翰璺ㄨ杞斤骞挎瀛ㄤぇ杈圭绯荤ュぇ缁浜缇茶鸿界缁瑙涓1锛缁绐瑙缁锛浣浜缁绐瑙

5-缇茶鸿浆杩浣涓5-缇茶虹撅剧ヨ缁锛

瀹浠缁瑙撮涓版5-缇茶鸿ョ瑙绁缁锛存褰卞绐瑙撮5-缇茶虹娴搴骞堕存5-缇茶鸿界缁氦缁存伴25-缇茶虹撅浣浜瑙5-缇茶鸿浆杩浣5-缇茶鸿缁ㄤ寰浣唬璋㈢3

缇界绌跺锛ㄦ靛灏(PET)纾辨(MRI)寰浜210涓ュ悍浜虹兢澶ц褰卞锋跺娇ㄥㄦ靛灏PET锛瀵瑰凡缁姝讳骸浜虹被澶ц杩琛惧奖锛缁琛ㄦ浜虹被ㄧ4涓5-HT浣5-HTT杞浣涓ㄧ借川瀵搴(╁/姣)楂搴姝ｇ稿冲崇郴4

浜虹被ㄧ4涓5-HT浣

浜虹被ㄧ4涓5-HT涓5-HTT杞浣涓ㄧ借川瀵搴

浠锛5-缇茶鸿浆杩浣哄涓ょ绛浣哄LS锛哄甫S绛浣哄5-缇茶鸿浆杩浣告惰藉浣L绛浣哄琛ㄧ楂杞娲绘э藉浣5-缇茶哄揩躲

绌惰〃哄甫S绛浣哄哄甫锛浼澧涓瀵瑰绉缁纰эL5-缇茶鸿浆杩浣哄锛藉缂х娲讳浠朵腑躲

惰锛涔绌惰〃5-缇茶鸿浆杩浣哄涓纰涔村苟娌℃浠涔崇郴锛绌跺30骞村ㄦ拌タ版板虹缇ょ堕扮版甯浠ユラ璇充5HTT浣哄虹澧瀵圭娲诲搴璇达缁琛ㄦ哄涓绉蹇纰т村苟娌℃崇郴5

杩锋朵绌剁锛璁╂浠板蹇纰璧锋杩琛璁よ锛浠娴蹇纰界卞涓哄卞冲锛姝よ瑕浠涓姝ョ绱㈠绌躲绛版涓澶╄涓绉绉瀛㈢罕瑙ｅ充娇ワ浠戒浼韬竟浜茶浜哄ラ杩剁哄ㄤ绁锛璁╁ぇ瀹跺璋搴涓涓娓澶ワ

[1] Chen J X, Pan H, Rothman T P, et al. Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception.[J]. American Journal of Physiology, 1998, 275(1):433-48.

[2] Lesch K P, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.[J]. Science, 1996, 274(5292):1527-1531.

[3] 妗,缃璺. 哄澶у缁绁缁璺褰卞[J]. 蹇绉瀛灞,2010,(09):1440-1448.

[4] V. Beliveau et al.. A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. Journal of Neuroscience 37, 120 (Jan 4, 2017).

[5] 宀抽,集寮,璁歌,浣瀹. 哄涓纰绌惰堪璇[J]. 缁ョ,2014,(32):4-5.

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