涓娉ㄦや骞达圭负浠涔浼瓒ヨ榛锛

圭绾ら夸锛ф艰澶ф椿娉硷绮浜猴杩涓瀹充婢婢澶х肩锛娣卞璁稿浜哄便圭姣插瑰榛搞榛灏惧榛ㄦ婀涓绱ユ浼涓″充圭浼璇粹圭芥ょ锛浼瓒胯榛锛杩′璇磋涓涓绉圭藉姣锛浜垮烘ョ灏辨姣

杩锛姣叉ョ锛涓轰涔圭榛锛ㄤ涔典浼榛锛插浠涔借介叉圭榛

灏绀猴濡楂涓╃ヨ涓澶寰浜锛寤鸿垮鸿涔涓涓

浠茶归㈡ヨ锛浠汉绫荤澶村涓凤遍茬ュ冲ㄧ姣ㄤ锛瀛ㄧ榛绱缁锛垮烘ユ讹榛绱缁浜х榛茬杩ユ骞蹭腑锛灏辩涓浜棰层

榛茬涓虹榛绱瑜榛绱涓ょ被锛榛绱娣辨诧褰茬棰绮瀵搴楂讹璧锋ュ涔氨诧瑜榛绱绾㈡层

榛绱瑜榛绱瑰锛灏辨浜榛妫姗榛界涓棰茬锛ㄧ韩涓涓甯锛褰㈡浜涓便绛涓绾广

榛茬褰㈡渚璧浜皑搁剁浣榛绱瑜榛绱涓ょ榛茬芥皑搞

皑搁堕皑哥澶宸撮锛涔澶宸撮ヨ姘у锛灏辩澶宸磋茬锛澶宸磋茬杞涓虹榛绱锛ㄨх辨皑告璋疯辩藉ㄧ′欢涓锛澶宸撮涓姘у澶宸磋茬锛辨皑板宸达缁杞涓鸿榛绱

瑙锛皑搁舵姣ユ绉棰茬抽锛濡涓皑搁舵椿ч浣涓界瓒冲榛茬锛瀹姣插氨浼娴锛濡皑搁跺ㄥけ娲绘э瀹灏卞介垮虹芥ャ

皑搁讹tyrosinase锛TYR哄缂锛涓TYR哄浜绐锛灏辨介烘ョ皑搁朵甯哥皑搁舵涓锛娲绘т究芥ｏ冲ㄥけ娲汇

ㄦ浠汉绫讳腑锛浠ラ茬缂轰负涓昏剁涓浜琚绉颁负藉锛TYR哄绐姝ｆ藉涓昏锛浜轰滑宸茬浜句涓TYR哄寸х浣癸涓浣圭瀵艰寸藉蜂跺涓ラ绋搴涓

ㄧ韩涓典绫讳技锛TYR哄涓浣圭锛褰㈡浜涓绋搴藉涓轰涓涓绉炬у哄藉稿哄锛浠涓杩绉хTYR哄涓衡娣″哄ㄨ浜涓娣″哄涓锛璇ュ榛诧哄C锛炬э灏卞藉宸у诧哄cb锛涔抽诧哄cs锛绫崇借诧哄ca锛绾借诧哄c锛哄涓cc甯哥瑙锛变ㄤ戒骇榛茬锛浠ヨ肩芥孩茬

界惰浜娣″哄稿浜茬哄Cヨ芥э浣浠炬х搴锛渚娆℃C>cb=cs>ca>c锛冲哄讹浼琛ㄧ涓烘存繁茬ｄ釜哄х躲杩涓猴瑕涓瀵规蹭涓涓′甯借〃杈鹃皑哥哄锛氨戒骇稿榛茬cb cs哄琛ㄧ轰涔cb cb涓cs cs涓涔寸姣诧姝よ涓ょ哄涓哄辨炬с

绾圭哄姝ｆcs cs锛姝ゅ浠函骞查ㄤ姣钩榛诧肩涔涓鸿茬灏鸿层

瀵艰存圭榛缃绁搁锛封

哄cs cs浼瀵艰寸烘ョ皑搁N-杩绯哄绋搴浣绋冲у宸浠寰瀵规俯搴涓烘娓╁害杈浣讹杩绉绐皑搁跺芥甯稿ュ斤皑哥榛茬锛娓╁害楂跺澶辨椿锛娉姝ｅ父涓虹堕榛茬冲杩绉绐皑搁惰藉甯稿ュ界涓寸娓╁害锛澶х害涓33

圭㈢锛灏惧反锛虫靛搁ㄧ娓╁害瑕姣浣娓╀搴姝ゅ甯浜浜ㄤ榛绱缁锛㈢缁澶у伴皑搁惰藉伐浣锛浜х榛茬璁╄垮烘ョ娣辨层韬共ㄤ娓╁害楂锛涓皑搁跺ぇ澶伴界舰宸ヤ锛垮烘ョ涔灏辨浜涔抽层

ㄤ浜娌℃姘板猴插浠寰浼锛涓诲姣板ぉ灏扁も浜锛寰榛榛㈤虎锛板ぉ藉藉ヤ浜杩涓澶缂锛瑕ぉ澶澶缁涓诲寮垫姘锛涓诲灏变浼榛

や圭ㄧ哥充集肩舵浜ゅ唬甯剁卞界绉涓涔锋哄涓cs cs瀹浠姣蹭浼琛ㄧ鸿绉瑰

锛缂哥

锛甯剁

锛卞界

杩绉哄绐╁ㄥ椹涓锛姝よ绉颁负椹绐锛himalayan mutation锛锛杩绉绐歌充㈢棰叉繁ㄩ叉歌归ㄥ涔负借茬插琚О涓衡椹琛ㄥ锛Himalayan phenotype锛锛淇绉扳硅诧pointed锛や瀛浜轰滑ㄥ璞榧缇绛ㄧ╀腑涔藉凡硅插轰绋冲浼硅插绯汇

锛硅茬锛

锛硅茬灏锛

杩蜂ワ圭榛涔璋灏辩稿ぇ戒

灏圭瀹浠濡瀛烘ユ讹变濡瀛锛浠ラ芥韬界姣骞村娓匡借茬ф娓辫斤伴垮烘ョ姣锛搞冲㈢ㄤ灏辫ヨ榛濡娲诲ㄨ瀵风版癸杩韬共ㄤ浣琛ㄦ俯搴借冻澶浣璇锛圭藉ㄨ韩藉榛锛褰诲娌负ゅ伐

濡圭涓虹叉绛瑕ㄤ姣璇锛绉绉ｅら惧椋椋锛伴垮烘ョ褰朵灏辨茬浜瑕抽垮杩绉姣蹭碉瑕寮哄姣灞ㄧ淇冲

锛浠跺界锛

锛垮ぇ浜灏扁

褰讹锋硅测х剁朵绉朵ㄧ╀

锛椹灏瀹锛镐借茬锛

煎涓榛绱缁戒浠浠负ゅ姣渚榛茬锛ㄧ宠锛榛绱缁杩璐璐ｈ绂诲骞宠　锛浜轰滑甯歌界宠锛灏辨涓烘涓浜界榛绱缁缂哄け浜

娣″哄哄涓cc界跺ㄤ戒骇姝ｅ父皑搁惰借诧浣瀹榛绱缁杩ㄣ浣甯歌界哄甫藉哄W锛瀹涓娣″哄骞朵稿藉哄W炬х锛涓涓娣″哄骞堕绛浣哄褰哄甫藉哄W讹榛绱缁渚夸姝ｅ父浜锛姝や璁哄娣″哄涔锛瀹戒垮轰韬芥や璁╂斤藉哄W剁х惰肩宠

や缃瑙cc哄甯歌W哄锛界芥浜借叉瑰哄SS绾ㄨ茶绋涓榛绱缁杩绉诲板ㄨ韩澶锛浣借叉瑰哄S浼荤杩涓杩绉昏绋锛瀵艰寸韩涓浜х借茬哄告SsSS绾借插哄村ぇ锛浜SS哄借插哄村ぇ拌浜ㄨ韩锛浜璧锋ヤ灏辨浜涓界濡借插哄瑕浜肩锛煎氨浼诧濡借插哄瑕浜虫碉ｄ杩虫典浼姝わ濡界借辩渚ц宠锛寰寰芥借叉茬肩ｄ渚ц虫点

哄涓ca cacc界剁璧锋ヤ借茬锛浣瑕涓哄甫藉哄W瑰哄S锛甯稿氨涓浼宠

锛楦抽腐肩界ュ渚ц宠锛甯稿ㄨ间渚э

锛杩圭界涓烘哄甫叉哄锛澶涓轰借插哄锛

 Lyons LA, Imes DL, Rah HC, GrahnRA. Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). Anim Genet. 2005 Apr; 36(2):119-26.

Giebel LB, Tripathi RK, King RA, Spritz RA. A tyrosinase gene missense mutation in temperature-sensitive type I oculocutaneous albinism. A human homologue to the Siamese cat and the Himalayan mouse. J Clin Invest. 1991 Mar; 87(3):1119-22.

King RA, Townsend D, Oetting W, Summers CG, Olds DP, White JG, Spritz RA. Temperature-sensitive tyrosinase associated with peripheral pigmentation in oculocutaneous albinism. J Clin Invest. 1991 Mar; 87(3):1046-53.

Kwon BS, Halaban R, Chintamaneni C. Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun. 1989 May 30; 161(1):252-60.

Benkel BF, Rouvinen-Watt K, Farid H, Anistoroaei R. Molecular characterization of the Himalayan mink. Mamm Genome. 2009 Apr; 20(4):256-9. doi: 10.1007/s00335-009-9177-6. Epub 2009 Mar 24.

Halaban R, Moellmann G, Tamura A, Kwon BS, Kuklinska E, Pomerantz SH, Lerner AB. Tyrosinases of murine melanocytes with mutations at the albino locus. Proc Natl Acad Sci USA. 1988 Oct; 85(19):7241-5.