ラ撅ワ绮惧璋缁规宸叉í绌哄轰锛

充缇わ浠缁杩寰澶锛ㄣ79涓寮哄井╃ヨ锛ㄥ╀瀛99瓒浼瀹瀹涓涓绗19-32杩14涓ヨ煎澶у浜瑙ｃ

缇や浠煎稿卞借锛瀹浠灞ㄦ浠藉戒撮瑕瀹浠ㄤ负浠ュ悍鸿础姣濡锛绫讳汉浣娉存娑告剁妞╃氦缁寸澶绯锛浠ュㄨ缇ょ甯╀锛杞瀵逛汉浣捐稿缁寸绱

杩缇や澶藉涓涓涓瀛

澶骞存ョ绌惰〃缇ゅㄦ浠匡濡ュ讳锛诧濡郴缁叉锛锛浠ｈ阿剧锛濡ヨ锛锛浼锛濡垫缁锛绛涓归借捣瑕浣ㄣ

寰澶浜轰寰跺版冲帮浠浠ヨ璋缇ょ缁锛浠ュ瑰浜虹ュ悍舵跺锛寰澶绉瀛宸茬ㄨ涓浜婵ㄤ汉蹇杩灞

浠澶╋磋澹灏辩澶у璁茶涓涓充缇ゅヨ浜锛瀹浠ュ浼瑙杩璋缁ュワ芥璋辩浜

缇ゆ涓

2013骞达磋澹ㄧ缇藉ｈ矾椤垮ぇ瀛Gordon瀹楠瀹ょ绉瀛锛ㄣ绉瀛蹇琛ㄤ涓绌舵锛

璇浠缁璇风涔绔锛娉ㄥ锛ワ浠ユ句釜灞锛

绠璇达灏辨涓风濡圭缇わ浠究渚块烘ワ杞Щ板锛缁瀹浠锛锛跺瀹浠寮楗插伙涓风ュ悍椋╋杞Щ浜濮濮缇ょ灏锛灏锛锛杞Щ浜濡硅缇ょ灏锛灏锛稿杈

杩灏卞璇存缇ゆ藉奖锛绉瀛浠㈠浜撮э浠浠灏灏惧ㄤ璧烽ゲ伙锋涓风ュ悍椋╋灏存病璧锋ワ

ワ绫讳技浜锛榧榧涔卞渚夸究ㄧ╋冲ㄤ涓瀛锛灏浼扮灏渚夸究锛缇ゅ氨ㄨ椁杩绋涓浜剁浜ゆ㈤┿

澶╃缁灏锛灏辨琚灏缁浼浜锛娌℃璧锋ワ缁翠浼浼缁灏锛

(o)舵杩绛濂戒锛

锛榧逛浜灞涔涓浼癸杩浠瀛涔锛浣浜轰琛锛涓藉锛浠ヨ瀛宠濂界锛甯浼圭涓瀹

涓锛濡缁灏涓ュ悍楂楂绯椋╋瀹灏辨澶灏浣ㄤ璧凤浜澶姝ゅヤ瀛锛涔涓浼ユ濂界锛朵涓浼

浠ワ瑕ワ绠′存案杩涓哄抽浜

浣浣涓瑕板锛浠惰寰澶娉ユ瑰缇ょ缁锛浠ヨ揪伴ㄥョ

AKK缁锛璋辩ョ锛

涓绉璋辩规锛灏辨绌跺缁╀ュ悍锛藉府╁ワ跺瀹浠

ㄣ补姣璁帮浠涔娌癸浼や涔锛夸涔ヨ锛涓涓浠缁杩2015骞翠椤规扮绌讹淇朵椋╂涓凤璁╄绫讳涓凤椋璋变腑补锛榧浼磋锛姣杈澶锛

椋璋变腑奔娌癸榧韬妫妫锛AKK涔抽告姝ф澶锛

娉ㄦ涓杩涓AKK锛瀹辨ㄧО锛Akkermansia Muciniphila锛灞惰娌℃涓缈昏锛浠ユ浠涓灏卞瀹AKK

娌℃浜轰宠捣AK47锛AK47杩风╃姝ㄥ府浣ワ

绉瀛璇达AKKㄦュワ纭寰璋憋

AKK藉榛恫灞锛瑰浠ｈ阿锛甯╂村介涓璁╀汉胯

瑰璇浣涓涓锛浜瀛AKK锛姣姝ｅ父浜虹灏100

浠ワAKK宸茬涓虹ㄧョ锛涔涓ラ娌℃姝ｅㄥ稿崇浜у锛涓界浠ヨ璇

撮璋辩锛寮跺AKK

锛绠璇村氨椋┿瀹界瑰у板烘涓绉绉瀵瑰ュ悍缁匡甯歌锛

浜轰滑宸茬杈‘涓㈣浜锛寰澶芥瀵规у板烘姝ф裤

褰讹涔峰峰璇浣锛瀹浠烘借藉烘AKK匡AKK浼椋╋浣烘AKK娌℃姝фｄ俱

ｈ戒芥惧板奸涓浜や灏辨涓芥AKK烘璧锋ョ

绛妗锛

2015骞10涔锛宸ヤ寰宸ㄥぇ锛寮堕翠浼寰婕匡瑕涓板璇锛浣ㄥ磋澹浜ㄣ绉瀛蹇涓涓己澶х寮宸ュ峰浜灏卞寰稿绠浜

浠缁路浠ｈ阿蹇瀵硅涓纾绌剁荤撅

浜规锛杩浠ュ寰寰寰澶磋浆锛浠ユ瑰板磋澹ヤ翰瑙ｏ

浠缇よ韩哄锛缁寰╅浼瀛哄缁瀛寮浜涓绉扮缇ょ绌舵规锛澶绫绘ュMulti-taxonInsertion Sequencing (INSeq)锛 ╃ㄩ搴ㄦ妫娴楗瀵逛缁缁褰卞锛村缁搴澶椋╃哄锛浠涓烘瀵绘扮浠ュ浠ヤ杩杩浜跨哄钩浜璺

绗姝ワㄢ″舰寤虹绐搴

蜂ヨ锛杩涓规绗姝ユ缁瑁涓″舰浠杩寰╅浼瀛楠娈碉瀵4绉浜轰甯歌缁锛瑙ｇ氦缁磋借锛靛绫绘涓や釜澶褰㈡浜绉锛杩琛浜哄绐

浠甯″舰杞骇瀛ュ板浠哄缁涓ヤ圭哄界涓уけ锛浠浜х浜涓涓瑰哄缂哄け绐杩璋瀹楠′欢锛瀵规釜绉锛浠藉堕浜稿绐搴锛㈠句涓婧杞骇瀛绐绉锛娑电浜蹇哄

ㄧ瑰澧涓锛浜绐块搴浠瀵艰村跺ㄦ翠釜缇や腑稿涓板害涔浣变″舰瀛杩哄缁娴搴浠浠ュ纭妫娴鸿浜绐ヤ癸纭绐哄锛浠ュ姣釜绐稿涓板害

杩姣杈涓ㄨ澧涓赴搴锛浠寤轰缁璁℃ā锛璁＄轰姣釜绐ㄨ澧涓ュ悍扳ュ悍扳捐浣绐哄甫绐哄灏辨搴璇ョ澧瑕哄

绗姝ワ寤虹妯℃浜虹被澧榧妯″

浜绐搴涔绗姝ュ氨缓绔浜虹被缇ゆā榧妯″浜浠浜虹被缁锛11?涓搴锛绉绘板ㄦ绂荤郴缁涓ゲ荤茬灏浣锛浣垮浠哄甫浜虹被缁锛涓轰缇よ搴ヨ浜虹被榧

跺瀹浠椋涓浜虹被椋╋浠ラ绯涓轰唬琛ㄧ稿瑗挎归╁浣妞╃氦缁寸ュ悍椋

绗姝ワㄦ娴缇ょ

涓ワ╃ㄧ浜浠ｆ搴规锛ㄦㄤ椋╅ゲ讳榧浣缇ょ锛浠ュ哄琛ㄨ揪

杩浜绐搴娴搴版浠娆℃轰藉浠哄灞㈢绌惰缇ゆ浣搴涓澧

杩瀵规搴版姣瀵癸浠浠ュ纭褰姣釜绐ㄦ惧ュ浣涓板害锛ｄ变浆搴уヨ瀵艰村哄界己澶憋涓板害捐涓绐究浠剧绐涓哄浠绐哄灏辨ㄨ涓澧涓捣瑕界哄

绗姝ワ惧板哄璇瀵瑰

究婵ㄤ汉蹇涓姝ワ浠藉惧版扮规ヨ缇ょ

ㄤ缁2013骞寸瀹楠涓浠浜灏浼缁灏瑕缁涔涓В绾ょ淮借

ㄦ扮绌朵腑锛浠瑙ｇ氦缁磋借ㄤ楂绾ょ淮ュ悍椋涓跨寰娆㈠揩锛涔昏缇ょ涓锛浣ㄩ楂绯椋涓氨涓涓瀛浣涓浠ヤ

浠藉惧颁绉规璁╁浠ㄨタ归涓芥蹇垮

杩Multi-taxon INSeq,浠瑙ｇ氦缁磋借涓涓哄绨绐滑ㄨタ归涓剧ず轰朵ュ悍扳锛剧ず鸿涓哄绨瀵硅В绾ょ淮藉ㄨタ归涓胯捣瑕浣ㄣ

ｄ浠涓浠ョㄥ剁瑰

杩浣澶瀹楠锛浠甯歌璋风╁绾ょ淮绱跨烘ㄨ绯涓哄绨搴╋浜浠冲ㄨ榧椋ㄦ按涓ュ绾ょ淮绱跨烘ㄨ绯锛浠瑙ｇ氦缁磋借稿涓板害涓涓瀛澧垮颁姣ㄥュ悍椋涓楂姘村钩锛骞朵锋椋╃瑰у绉瑰э瀹ㄩ璇浜浠璁俱

凤戒杩病锛娌″崇郴锛澶с

涔变涓涓缁瑙ｈ涓缁锛骞朵负瀹搴ㄥ伴甯告ㄣ

涓轰涔璇风磋澹充涓界ㄤAKK涓灞璁ㄨ锛

戒涔锛褰浣涓绉浠ュョ锛や浠ョ存瀹锛ㄦ撮璋辩浠ュ璇惧拌借瀹ㄨ垮村ソ锛

绛哄锛纭搴╋瀹楠璇藉ㄦ板ㄤ灏卞浠ュ

濡锛AKK灏变瑕璺姝ф绛浜绯绛浜浜瑕ワ归瀵AKK锛芥

讳ヨ锛杩涓规绔, 灏卞涓绌堕」棰浜猴缇界瀛㈠诲㈠㈠＋Jeffrey Gordon璇达涓轰缇ゅ界绌跺瀹浜虹锛剧ず浜浠浠ヨ璁＄ュ瀵硅缇ょ绮惧璋

绮惧璋锛灏辨璇翠腑跺璋

Everard A et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71.

Dao MC et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2015 Jun 22. pii: gutjnl-2014-308778.

Wu M et al. Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides. Science. 2015 Oct 2;350(6256):aac5992.

Cani PD, Everard A. Harnessing Genes and Diet to Fine-Tune the Gut Microbial Fitness. Cell Metab. 2015 Nov 3;22(5):754-6.

Caesar R et al. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling. Cell Metab. 2015 Oct 6;22(4):658-68.

Bindels LB et al. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol. 2015 May;12(5):303-10.

辩缇藉ｈ矾椤垮ぇ瀛磋澹卞瀹

磋澹娓ぇ瀛藉2002绾ф″锛寰╃绌堕寮т汉Jeffrey Gordon寰ㄧ锛2015骞淬绉瀛蹇纾璁烘绗浣