甯妫涓ょ惧勾

甯妫绉甯歌骞存㈡х剧锛ㄤ汉缇や腑姒骞撮澧夸虹缈诲澧裤规璁★60宀浜虹兢ｇ涓0.25%锛浣70宀舵ｇ灏变1%锛80宀舵ｇ绾负2.5%,[1]变芥澶浜汉榫舵锛藉妫浜烘板浜ュт舵锛规藉涓椤圭绌讹2005骞存藉妫ｈ渚扮害涓199涓浜猴ㄧ绾负410涓锛棰璁″2030骞存藉妫ｈ浼杈惧494涓浜猴浜烘颁瓒杩ㄤ浜烘扮涓[2]

ㄨ丹瑁歌８板㈠锛甯妫灏卞堕涓疯椋浜虹被褰浜钩骞达惰浠娌℃娉诲杩涓剧锛涓杩椤惧瀹绌剁浠ュ锛瀵瑰妫绌舵按骞虫Н绱颁瀹绋搴浠瀹璁よ渚夸涓涓川椋璺

浠骞存妫浜惧ㄥ勾,[3]浣姝ｅ剁绌舵澶ф杩澶ч介涓ㄨ浜骞达灏卞ㄥｉ浠涓锛浠ヨ插寰灞锛╃藉涓澶绌朵涓锛涓杩ㄧ瀛灞浠澶╋浠ㄦ辩镐俊诲甯妫杩搴澶уぇ蹇

璇诲浣夸汉猴椤捐涓ょ惧勾绌惰灞锛浠ㄨ涓绌堕涔ｄ浣绉瀛卞浜╃锛楂浜板锛浠浠豢浣ョ┛瓒杩锛跺鸿逛负甯妫绌舵杩瑰姒瑷锛杩涓ょ惧勾浠ュぇ村涓轰互涓涓ㄥ

涓璇甯妫

堕村1817骞达卞戒鸡涓荤棣娆℃ラ浜6渚棰ゆ剁剧锛骞跺琛ㄤ涓绡涓恒棰ら夯广璁烘锛涓轰璁ゅ浠锛灏变娇ㄨ浣涓Parkinson澶уか瀛藉浜Parkinson`s disease锛涔灏辨浠炕璇甯妫锛浠瀵硅涓剧涓浜杩ㄧ剁堪娌跨ㄨ充锛姣濡琛ㄨ缂电淬㈤姝ヤ炽蹇ч绛锛浣朵骞舵病浜虹璁ょヨ藉涔浼ㄨ浠2500骞村榛甯缁涓瀵硅绉棰や负涓昏剁剧堪

James Parkinson

棰ら夯广

浜瀵荤瑙ｅ妫剁娉

ㄥ甯妫95骞村1912骞达寰峰界瀛Lewy浠浜Alzheimer涓璧峰PDｈ缁缁杩琛绌舵跺浜扮锛璇磋浣寰浜Alzheimer锛浠灏辨藉骞寸村绉瀛锛剧搴藉涓浜浜烘甯妫涓凤垮规捣榛骞寸村锛存浣跨ㄤ缁涓藉涓澶уソ澶灏辨浼璁╃浜鸿繁瑙寰颁茬姝ц锛杩浣Lewyㄧ涓PD浜鸿涓涓浜寮甯哥藉㈠锛浜氨浜浠ㄧ绌剁Lewy body,璺浣

1919骞达绉瀛搴锋灏卞浜PDｈ澶ц榛璐ㄩㄤ虹浜绁缁涓㈠け锛浣剁涓绘瀛借涓虹ㄥぇ绾圭朵锛涓娆＄ㄤ灏颁汉杩杈癸浣ョ浜锛村1960骞达缁翠绾崇绉瀛PD浜虹汗朵澶宸磋烘按骞虫鹃浣浣蹇汉浠氨锛娉澶宸磋虹婧澶存ㄩ璐ㄩㄤ锛澶宸磋烘绉绁缁璐瀹浼缁浠甫ュ垢绂瑙锛浣己灏澶宸磋哄涓姝㈡瑙涓板垢绂ｄ绠锛跺瀵瑰妫浜烘ヨ借繁浼诲氨垢绂锛寰浜涓锛荤寮濮浣跨ㄥ乏澶宸村PDｈ杩琛娌荤锛村扮ㄦ浠ㄤ娇ㄨ涓┿1987骞达娉界瀛璺瀵逛浜瀵瑰乏澶宸存病浜轰娇ㄦ繁ㄨ烘锛涔浠ユ炬瑰ｈ杩ㄧ讹杩涓娉ュ灞涓虹存ㄧ浜虹剧疆垫锛惰充ユㄥ乏澶宸存娣遍ㄨ烘芥瑙ｅ妫剁浣冲娉

涓娣卞ヤ瑙ｅ妫哄

濡璇磋涓ょ惧勾涓澶х绐存涔锛璁や负1997骞寸辩瀛Mihael甯㈤浠ラ浼甯妫寸哄浼浣课-绐瑙歌介璇锛缁寮璧峰妫锛浠寮绉瀛浠绱PD哄剁板ぇ锛骞村锛绉瀛浠瀹浜璺浣涓昏灏辨-绐瑙歌斤涔ㄨ涓骞达浠辩灏钩蹇变妫患寰涓胯颁骞达ㄨ20骞撮寸瀛缁浜伪-绐瑙歌芥浠ヤ板ュ悍缁缁褰涓锛骞朵杩瀵瑰甯瀵圭剧杩琛浜锛哄舵诞烘按㈡鸿澶绉╂不PD锛姣濡ㄥ哄琛ㄨ揪杩绋涓氨骞叉拔-绐瑙歌界锛杩娉浣垮蹇唬璋ㄦ娲插凡缁杩淇ょ缁娌荤╂PD╀甯锛涓杩璁稿╁杩琛涓村璇楠锛杩瀵逛宸澶宸村娣遍ㄨ烘宸茬PDｈヨぇ浜锛涓瀵瑰妫╂绛ヤㄥ绌朵腑锛ㄧ剧濮舵灏卞浠ュ敖╂不锛浠浼ㄤ浜佃板荤浼璁╂ｈ涓存归琛涓烘规板磋浠ュ绾挎＄骞虫搴ュゆｈ凡缁虹浜杩ㄧ跺璁ょラ纰

剧ヨWarning signs

娴骞寸锛ュ锛浠绌跺妫杩涓ょ惧勾ョ锛浠ｇ瀛灞瀵圭剧绌跺娌荤浜х浜宸ㄥぇㄥ锛涔璁稿氨ㄤ绔杩浜锛涓浣PDｈㄨ╄楠涓寰浜寰濂界锛璇PDｈ瀹跺浠涓逛俊蹇蹇锛涓绠℃藉杩姝ヨ藉灞锛绉杩姝ヤ浣垮ㄤ汉绫婚藉锛寰锛棣藉荤澶у虹诲㈢缁╁ 姹楣

[1]PD娴琛.

[2]Dorsey, E.R., et al., Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology, 2007. 68(5): p. 384-6.

[3]Drew, L., Two hundred steps. Nature, 2016. 538(7626): p. S2-S3.

娉绔变腑芥板绉棣浣浣涓汉甯锛杞浇璇锋敞哄