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や虫锛颁杩颁朵规锛姣濡ㄨョ（纰娲憋姣濡纰榛绮究濂垛[1]

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浠ュ虫浠ユ尖璇存锛寮濮ㄥ浠存浼浠娉㈠搴颁澹寰风瀛锛界涓浜稿崇璁拌浇[2]

骞冲璁猴ㄧ浠ｅ瀛诲璇浠ュ锛涓介芥涓浜ㄦ┿ㄧ╃崇跨╂不剧规浣规骞朵涓瀹ㄢ浜剧浼缂瑙ｏ浜浜哄姣杈寮猴浠藉圭按灏辫繁濂戒

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1763骞达卞界涓浣荤锛卞痉锋锛Edward Stone锛锛颁涓浜炬ｈ炬辩璧风瀵锛朵澶х圭规姝ゅ锛杩藉璧蜂弗澶寸涓轰缂瑙ｈ浜讹冲颁虫浠虫（棰绮锛姣20棰锛绾1g锛涓1浠斤ュ版姘撮锛姣灏剁浜烘1娆°缁锛浜虹垫濂借浆

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褰剁荤浠镐俊锛涓甯缁浜涓宸存锛蹇朵浼缁浣涓棰绾㈡ｏ寮璧风剧版癸瀛ㄦ不规[3]ㄧ瀹跺浼浼跨淇′腑锛瑙ｉ锛鹃甯稿虹ㄩｄ娼箍板猴虫板ソ娆㈡疆婀匡浠ワ虫芥不俱

杩绉璇存肩锛娌￠锛ㄣ绁渚渚ｃ涓搴稿ぇ甯姝ｆ杩绉筹娌诲ソ浜ㄨ姣

绉瀛锛ュ氨涓浼杩绋

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涔涓や欢浜澶у颁杩浜瀛浠虫绌躲涓伐涓╁斤浜浜[4]宸ヤ╁界ㄨ告苯哄浠ｄ浜哄锛浣垮冲ㄥ浜т锛姣濡绾虹锛稿灞甯绾哄烘ワㄧ锛瑕崇ㄥ灏卞椤诲缁瀹涓层涓虹绉锛褰剁娆ф床蹇椤讳绉涓瑰藉害锛灏辨变滑涓斤杩杩涓瑗挎ュ氨浠峰间锛19涓绾锛跨翠涓轰浜澶烘娲查告杩琛璐告浜锛杩涓姝ュ浜己

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1828骞达灏奸绌舵瀛Johann A. Buchner浠虫腑颁绉娣￠茬朵锛杩灏辨按ㄨ凤跺朵藉瀛浠揩璺杩锛ぇ╃瀛锛姘存ㄨ峰浠ュ瑙ｄ负姘存ㄩ革娉界H. Lerout瀵规绾规杩琛浜硅锛浠纾虫腑寰颁涓姘存ㄩ搞[4]

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1964骞达瀛浠锛垮规杩跺绉抽剁被娲绘эュヨВㄧ[6]虫锛垮规瀵规浜宸茬杩灏惧０锛涓杩锛垮规浜杩娌℃缁锛冲浠ヨ锛寮濮

扮╁虹锛垮规肩灏辫鸿涓杩锛╃骞冲瑕辫垂4浜胯遍卞15骞寸堕达姣勾20~30绉拌缇介╃灞瑰[7]灏辩卞璧凤浜轰滑存绛寰璧枫姝わ瀵绘炬ц╃扮ㄩ锛瀛浠涓涓瑕浠诲°

浜涓绾腑锛瀛浠垮规浠ユ惰灏跨娲绘э浠蹇琛绠¤褰㈡浠锛垮规韪浜棰插琛绠＄剧璺杩骞存ワ绌舵存剧ず锛垮规瀵逛磋藉ㄦㄧㄩ

锛冲绌舵娓╁锛[8]

荤

惰充ワ垮规浠舵ㄦ涓哄箍娉┿ラ璇达姣勾ㄧ瑕娑2000浜跨垮规锛稿浜釜浜烘勾20痉芥荤灏垮规璁＄恒姹借溅骞跺锛璁や负痉戒澶ф变涓[8]

绾佃垮规灞锛㈣界拌瀛涓姝ワ涔浣浜涓灞杩涓界跨锛缇界濂ュ浠绛绛绛绛锛濡浣浠捣芥ㄧ╄川涓涓虹璺嚎锛釜瀛姣惰涓戒寰涓

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[1]JACK D B. One hundred years of aspirin[J]. The Lancet, 1997, 350(9075): 437.

[2]FRIEND D G. Aspirin: the unique drug[J]. Archives of Surgery, 1974, 108(6): 765769.

[3]WICK J. Aspirin: a history, a love story[J]. The Consultant Pharmacist?, 2012, 27(5): 322329.

[4]WEISSMANN G. Aspirin[J]. Scientific American, 1991, 264: 8490.

[5]垮规涓轰跨涓琛帮- FT涓缃[EB/OL]. [2017-05-13]. http://m.ftchinese.com/story/001041604.

[6]The science behind aspirin[EB/OL]. [2017-05-09]. http://www.creatingtechnology.org/biomed/aspirin.htm.

[7]ARONSON J K. Old drugsnew uses[J]. British journal of clinical pharmacology, 2007, 64(5): 563565.

[8]椹. 垮规ュ[J]. 扮, 2014(6): 4647.