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斥寮缁濂ョュ锛涓锛

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楸块奔绁缁锛浣垮瀛浠浜浜绌剁锛寰垫硅锛缁浜浠浠璇璇寸姐

锛寰垫绁缁锛[3]

寰蹇瀛浠锛ㄧ缁澶锛瀛ㄤ涓瀹靛宸杩绉靛宸辩澶绂诲锛缁澶绂诲缁剧瀛锛缁存褰绁缁跺拌冻澶澶х烘讹缁瀵逛绂诲у锛绂诲娴ョ锛绂诲娴ュ浼杩涓姝ュ缁瀵归绂诲с浜灏辫杩搴寮璧峰瀛寮圭镐凤ㄧ缁涓锛褰㈡涓涓х垫涓杩锛瀛寮圭ㄤ涓涓涓绁缁村椤诲澶浣跨ㄣ浠ワㄩ绂诲澶чョ讹缁剧瀛寮濮澶娴锛骞堕娓锛灏绁缁澶靛宸版甯告按骞炽

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锛绁缁村杩绋锛[1]

杩涓遍濂(Alan Hodgkin) 璧ラ(Andrew Huxley)瑙ｅ崇浠浠涓ゆ圭寰垫ラ笨楸肩缁锛涓规娴楸块奔绁缁靛锛涓瑰璐璐ｅ楸块奔绁缁娉ㄥョ垫褰妫娴扮靛讹歌靛浠惰婵娲伙跺瀵圭缁杩琛琛ュ匡澶浜澶琛ャ灏浜灏琛ワ灏绁缁靛宸淮ㄨ瀹姘村钩杩凤灏辫界绌舵涓靛姘村钩涓锛绂诲剧瀛杩ㄦ点

锛靛冲锛剧ユ锛mednur.com锛

杩灏辨靛虫瀹杩扮缁村哄剁抽濂璧ラ姝よ寰浜1963骞寸璇鸿灏诲濂

锛宸濂锛锛璧ラ剧ユ锛nobelprize.org锛

褰讹绉瀛绱㈡病姝㈠扮寰蹇氨ヤ锛绂诲剧瀛锛璺ㄨ杩ㄧ锛

绌剁涓繁ワ瀛浠锛ㄧ涓锛瀛ㄧ涓浜规杩浜灏卞哄虹宸ヤㄩ涓凤璁哥瑰绂诲杩绂诲璁ら绂诲锛剧瀛瀵归剧瀛捐

靛冲浠ョ娴涓涓涓绂诲娲诲浣浜涓杩浜灏ㄢ锛瀹灏辨戒负浜

1976骞达寰峰界瀛灏锛Erwin Neher锛ㄥ硷Bert Sakmann锛瀵圭靛虫琛浜硅杩涓硅锛璇村ぇ涔涓澶э村抽浠浠寰垫ョ缁锛稿锛浠浠寰垫藉璐锛浣垮缁琚搁扮寰垫1981骞达浠浠硅浜杩涓浣垮杩涓灏琚稿ョ寰垫缁锛ㄧ靛瀛涓朵ㄥ缁浠讳璺ワ涓璺涓绠＄涓涓辨澶灏绂诲荤垫灏锛杩靛缁锛浠ュ瑙娴琚镐杩涓ㄥ浣垮绌跺涓瀛锛涓哄姐[4]

锛崇ず撅剧ユ锛haikudeck.com锛

杩灏辨虫瀹瀛绌剁浜娆￠璐灏诲濂[5]

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虫虹寰蹇寰浜瀛浠涓杩锛抽瑕浠ㄥ绮惧锛涓浠浠锋奸锛涓浠锋甯灏辨充拱锛涔寰绛涓骞淬

锛崇郴缁锛[6]

1987骞达腑绉澶у锛拌瀵颁虫骞块鸿剁稿充华ㄣ涓ゅ勾搴峰甯绌跺锛跺轰涓介虫惧ぇ杩浜1骞达涓界瀛浠ㄨ浠绗娆¤褰颁绁缁垫涓轰腑界瀛宕璧峰浜烘寤鸿锛濂瀹浜瀹虹[7]

濡浠锛虫凡缁ぇ涓烘锛骞挎娲昏ㄧ瀛稿崇绌讹姣濡缁娉绁缁瀛╃绛棰绘涓澶╋虫杩躲涓杩锛涓ょ惧勾ョ绱㈠绋锛颁唬瀛浠蹇琛锛浼涓磋

[3]BRETAG A H. The glass micropipette electrode: A history of its inventors and users to 1950[J]. The Journal of General Physiology, 2017, 149(4): 417430.

[4]HAMILL O P, MARTY A, NEHER E绛. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches[J]. Pfl眉gers Archiv European journal of physiology, 1981, 391(2): 85100.

[5]椤惧ㄤ. 1991 骞磋璐灏濂寰娲荤蜂绯[J]. 绉瀛绘, 1992(2): 45.

[6]BHARGAVA A, LIN X, NOVAK P绛. Super-resolution Scanning Patch Clamp Reveals Clustering of Functional Ion Channels in Adult Ventricular MyocyteNovelty and Significance[J]. Circulation Research, 2013, 112(8): 11121120.

[7]ㄤ. 褰浠ｄ腑界界瀛涓浣鸿矾浜[J]. 瀛, 2015, 67(002): 235236.