绮绉绘锛甯㈠绱ф杩锛

浠澶╃涓昏浠舵渚夸究

璇璇达绔锛界朵借锛浣澶у搴璇ヨ璁颁姝ｇ涓昏烘芥究渚裤

浠澶╁澶у浠缁涓昏瑕瀵规涓や釜娲锯涓ょ涓濂界缁锛

Vancomycin-resistant Enterococcus (VRE)锛涓绱

Klebsiella pneumonia锛虹蜂集

杩淇╁瀛锛灏辨ぇ娲撅

绮浠借瀹崇缁涓锛涓轰缁杩涓ゅ寮

棣锛涓哄浠卞涓ラ锛缇界浜轰腑锛澶ф10%涓ょ缁锛瀹浠琛缃锛璋

舵锛涓哄浠虹锛涓互ㄦ绱瀵稿炽

绉瀛浠锛濡娇ㄦ绱灏浣锛绉绘涓绱浠ュ虹蜂集锛锛锛12澶╀涔病浜杩涓ょ缁韪奖锛

椋浜绱灏浣绉绘杩涓ょ缁锛12澶╁瀹浠ㄨ浠跺楂涓涓锛

寰撅绱浣跨璁╄涓ょ缁ㄨ村瀛锛浜哄灏灏辨村姝ゅ

杩负浠涔璁╂浠ョ捐璇с

杩寮炬病浣跨ㄨ绱灏缁ㄥу褰卞璁16S rRNA剧ず绾㈣诧绾㈣茶澶锛缁伴澶

杩寮炬娇ㄨ绱灏缁锛绱ф杩缁姝讳激ㄩ锛涔涓扮孩茬杩逛

绉瀛浠涓猴绱瑰箍璋辨绱锛藉蹇汉浣寸锛浣涔朵姝昏涓璁稿锛杩浜ㄥ钩惰藉娉涓浜╄川锛舵瀹崇锛灏卞涓绱浠ュ虹蜂集锛裤

绱姝讳杩浜瀹よ瀹崇渚胯藉蹇颁负浣姝逛

涓浠濡姝わ浠户缁ョ涓ゅ浠や汉伴撅

杩浠ｈ〃浜娌℃浣跨ㄦ绱灏缁涓ㄥ锛澶у娉ㄦ颁袱＄借绾夸寸界澶翠涔锛

涓ゆ＄借绾挎轰涓″～婊＄豢茬甯锛杩♀甯榛恫灞锛Inner Mucus Layer锛锛瀹涓锛介绘缁╂ｅ颁澶锛浠叉涓缁ヤ镜宠娑层

娌℃浣跨ㄦ绱锛杩涓恫灞寰锛界澶村匡锛浣跨ㄦ绱杩

借茬澶寸寰澶锛

绱璁╁榛恫灞搴惧锛杩崇涓缁村ぇ轰ヤ镜拌娑蹭腑

姗娣涓烘斥锛褰缁颁琛娑查锛涓浜介戒浠卞浜茬锛遍╃浜轰锛藉磋琛卞浜虹ュ悍骞朵锛瀹崇缁浠戒瓒杩涓轰锛绾风悍娑ヨ娑蹭腑浼ゅ

捣ユ瑙寰锛

浜虹涓涓绘介瑕浣跨ㄦ绱ュ浜锛ｆ浠涔娉璁╄缁㈠姝ｅ父

绉瀛浠渚浜涓绉界规绮绉绘锛Fecal Microbiota Transplants, FMT锛

灏辨ュ悍浜轰究渚块缁绉绘颁娇ㄤ绱浜虹涓锛杩绮锛瑕涓锛

捣ユ瑙寰跺锛浣杩芥浜轰界绉瀛规锛

绮绉绘浠ョㄥ韬瀹楠

绉瀛浠娇ㄨ绱灏渚夸究锛娣峰PBS婧舵恫涓缁浜浣跨ㄨ绱灏锛璇村瀛浣杩藉锛锛ㄥх涓绉瀛灏PBS婧舵恫缁浜浣跨ㄨ绱灏

缁锛椋ㄤ渚夸究灏涓虹蜂集浠ュ涓绱伴句锛10澶╀涓涔病杩涓ょ缁浜锛瀵圭х涓灏涓杩涓ょ缁伴涔

璧锋ワ绮绉绘锛跺跺浜癸浣跺╀

涓杩姝ｇㄥ颁汉韬锛绉瀛浠绾究渚块缁锛浜跺锛瀹涓涓浼璁╀汉灞

ㄥ藉锛绮绉绘宸叉娌荤伴炬惰借锛CDI锛渚浜

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涓锛璇翠浠ュ汉绫诲浠ヨ凤灏骞磋交跺ュ悍渚夸究堕淇璧锋ワ拌跺垮烘ョ繁娌荤

杩榄э涓ラ澶уヤラ涓戒缁诲涓浜轰腑榛锛浠ュ婊′璁ㄧワ涔戒ㄦ病绉瀛

杩澶澶瑕绉瀛绌剁‘璁わ

浠澶╃绔灏卞拌锛绁挎ㄥ濂芥濂斤椤猴姘椤猴ぇ椤哄

Caballero, Silvia, et al. "Distinct but SpatiallyOverlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium andCarbapenem-Resistant Klebsiella pneumoniae." PLoS Pathog 11.9 (2015): e1005132.

锛浣锛灏 PhD Candicate & 锛

绔锛杞璇烽欢绯伙lanch@biomed.tsinghua.edu.cn