冲浣锛浠涓瑙锛

涓ュ悍楗涓瑙寰浣藉借浜洪胯锛杩负浠涔锛

绉瀛浠缇ょ绌惰娣卞ワ姝ｅㄦ寮楗╅缇も寸瀵崇郴锛骞跺瀹浠璧峰冲浜灏

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1锛涓楗浼褰卞灏缇わ╅瑰锛冲

2锛╅瑰锛濡跺樊锛浼褰卞缇わ娉ㄦ句腑榛插绠ご锛锛

3锛灏锛娌℃缇わ涓绠″浠涔锛瀹戒浼锛瀛瀵逛汉涓浜鸿瀛涓芥锛ㄥ箍璋辨绱娑澶у扮锛浣涔灏卞けュ悍灞浜锛锛

绌跺锛缇や杩浠ｈ阿浜х╁奖涓㈢缁郴缁锛骞查浜虹琛涓恒涓ヤ椁浠涔锛芥辫缇ゅ澶ц涓璧峰冲

浠ワ杩浜绌跺ぇ姒璇存楗╅缇も涓瑙崇郴锛

瀹浠花寰娆翠涓灏冲浜浠

浣涓杩涓琛锛

涓㈢瀹癸濡光卞妞板缁澶у澶锛绗姣濂藉お澶锛澶у璇伙

3寮惧甫浣锛锛胯锛缇や寸╂ㄦ浠

浜鸿涓轰娑寰浜烘粹锛モ搴瀵蹇椋搴璇モ绱瀵瑰锛灏涓哄ヨ胯

浣涓轰涓父甯稿ㄧ绐昏璇瀹靛楠涓椤夸涓椤跨锋ュ涔涓绱胯锛甯搁茬濡瑰锛灏冲锛瑕ㄩ涓绉瀛瀹娓斤

2014骞10锛浠ヨ插Weizmann绌舵ㄤ椤剁骇瀛缁涓琛ㄧ绌舵绉帮ㄥ涓昏椋堕寸璋涔涓锛ュ悍缇ょ跨舵煎寰锛颁贡瀹夸富╅锛灏瀵艰磋缇ゅけ琛★骞朵涓荤浠ｈ阿绱涔辨稿炽

浠涔涓变澶╃绗1寮锯

绉瀛杩查ょ╅璋哄澧骞叉 (妯℃跺樊)锛ュ共板涓诲姝ｅ父╅锛灏娲诲ㄥ椋琛涓洪藉け寰

寰缂哄け瀵艰翠藉ㄥ缇ゅけ璋灏杩峰け璋缇ら杩绮绉绘锛绉绘缁灏绉绘灏ｈヨ¤绯涓惧浼澧锛

杩涓绌跺ュ父娲绘寰澶уず锛荤璧锋ュ氨澶╃绗2寮锯

棰榛解缇ゆ煎寰澶辫　 胯锛

浠ヨ锛璇ョ绌朵缇ょ瑙搴В浜涓哄ョ╅у插库浜虹兢锛姣濡ｄ澶宸ヤ汉胯法跺虹绌轰腑椋浜衡锛瀹规虹浠ｈ阿绱涔辩躲杩涔虫筹ｇ瑰哄樊辩瀹规

ｈ浜璞″哄舵涔绗3寮炬ヨ2015骞寸纾绌讹

缇ゆ╅淇″碘

杩借ュぇ瀛绌跺锛浠浠郴缁х绌朵煎寰瀵瑰ュ悍浠ｈ阿褰卞锛缇や浠ㄨ缇ょ锛存ㄥ跺浠ｈ阿浜х╂归㈡煎ㄦ¤寰锛杩浜锛姝ｆ卞涓荤楗╅椹卞ㄣ遍楗璇卞缇ゅけ璋锛浼颁贡寰╁瀹夸富涔存煎寰缃缁骞宠　锛杩褰卞浠ｈ阿ヨ

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楂楗浼颁贡寰ц缇ょ姝ｅ父缁涓斤瀵艰磋缇や俊寮甯革锛ョ娉￠~镐釜涓~浣~锛

2锛缇ゆ淇″

姝ゅ绌堕浜瀹夸富轰瀛瀵硅缇ょ褰卞锛绌跺锛缇や浠ュ杩ヨ瀹夸富瀛锛璇存涓荤╅涓缇や寸浜ゆ锛

ㄤ渚涓寰稿崇淇″锛light-dark signals锛典锛璁鸿椋浣楂╋榧ㄥㄧ╅哄琛ㄨ揪芥惧锛缇ょ己澶扁╅锛锛涓х告浣骞朵澧杩绉哄琛ㄨ揪寮甯镐浣ㄢ瀹堕ㄥ涓涓村ㄢ杩ㄥㄣ

3锛浠ｈ阿╁涓

绌跺己璋浜缇や唬璋骇╁ㄨ瑰寰瀹夸富浠ｈ阿芥归㈢藉版剧ず锛楂浣楗涓璇卞瑰缇や唬璋骇╃锛瑰捐革浼存璋缁╅哄琛ㄨ揪锛渚濡锛浣澶妯″涓ヤ搁灏ц涓╅哄琛ㄨ揪锛骞舵瑰惰〃杈剧镐锛涔灏辨锛杩浜浠ｈ阿浜х╀瀵间涓㈣缇や涓荤╅涔粹浜ゆ

ョ锛缇ゅ胯涔达杩杩涔卞~界跺璇绱涓涓汉锛革锛浣瑕澶у娉ㄦ辨ㄧㄤ涔风椋╁浠ｄ环ㄧ卞ュ悍锛お硷锛锛

1.Thaiss et al. Transkingdom control of microbiota diurnal oscillations promotesmetabolic homeostasis. Cell. 2014 Oct 23; 159(3):514-29. http://dx.doi.org/10.1016/j.cell.2014.10.020

2.XueLet al. Time in motion: the molecular clock meets the microbiome Cell 159, October 23, 2014. http://dx.doi.org/10.1016/j.cell.2014.10.020

3.Leone et al., Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolismCell Host & Microbe 17, 681689 May 13,2015. http://dx.doi.org/10.1016/j.chom.2015.03.006

4.Emily V et al. Message in a Biota: Gut Microbes Signal to the Circadian ClockCell Host & Microbe 17, May 13, 2015. http://dx.doi.org/10.1016/j.chom.2015.04.013

5.Rudicet al., Circulation, 112 (2005), pp.27162724