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ユ瀛绌舵绉瀛绌朵腑蹇锛RIKEN Brain Science Institute锛Toru Takumi 棰瀵肩绌朵汉浜ㄧ╂ュ抽哄躲绌舵剧ず浜澶ц╅哄舵浣瀵逛瀛ｈ藉ぉ堕胯琛缂浼撮GABA锛姘ㄥ轰革娲诲杩涓缂杩瑰绁缁姘╂伴瑰瀹

瀛ｈц跺浜哄ㄧ╅藉瑕锛骞朵杩绌惰〃绉璁版剁卞ぇ涓稿ㄤ瀹锛杩涓ㄤ剁浠ュ父煎寰杩涓ぇ哄瑙浜ゅ涓革SCN锛suprachiasmatic nucleus锛锛瀹ㄤ澶24灏跺寰琛ㄨ揪瑰堕锛clock锛哄锛浣骞朵绁缁戒互稿濂琛SCN涓涓や釜哄哥锛骞朵奸跨澧锛杩绉搁撮浼澧澶с

涓轰瑙ｈ锛绌朵汉浣胯ㄥ归ㄦSCN灏娲诲ㄩ挎ョуョу惊澧涓骞舵涓澧涓堕哄Bmal1琛ㄨ揪姘村钩涓烘锛挎ョхㄥ归ㄥ哄寰Bmal1姘村钩镐宸ョх姝ョ寤烘ā棰娴杩涓や釜哄杩骞朵绉娌锛杩涔ョу挎惰ㄥ哄哥

绌跺㈤绁缁璐GABAㄨ涓杩绋涓ョ抽ㄣGABAㄥぇ澶版典浼剁缁娲诲ㄣ惰锛涓浜SCN绁缁浜瀹涓GABA婵娲荤棣甯Jihwan Myung 瑙ｉ帮褰绁缁ㄦ隘╂按骞冲楂讹GABA灏变寰寰娲昏浠娴锛绌胯SCNGABA界杩绉琛ㄦ涓ょ兢绁缁寮告辨ュ

褰绌朵汉绘GABA娲绘ф讹挎ョх涓宸ㄥぇ镐撮娑澶憋骞朵Bmal1姘村钩ㄦ寰ョх绫讳技杩琛ㄦGABA瀵硅ㄧSCN规褰卞

涓轰娴璇杩绉璁撅绌跺㈤娴朵涓ょ哄Nkcc1Kcc2琛ㄨ揪姘村钩锛瀹浠璐ｆ隘╃杈ュ杈恒绌朵汉ㄩ挎ョSCN涓杩涓ょ哄琛ㄨ揪瑰锛浣垮姘╄ユ村杩浣垮GABAㄥㄨㄦ娲汇绘隘╄ュ交搴娑や挎ョх涓镐撮锛骞朵ā棰娴ｆ凤浣SCN12灏剁ョуㄦ涓缁锛灏卞ョх涓枫

Myung璇达灏卞朵ㄧ╀凤浠韬涔ㄤ存ュ瀛ｈх芥奸垮害绐舵瑰藉翠浜浜轰骇涓ラ蹇纰ラ濡浣璋磋繁ㄧ瀛ｈх╅府╃姝ｈ绉绱涔辩娈点

锛璇瀹★Y Chen锛涓ョ杞浇锛