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拌浜骞寸稿崇绌朵浣缁父躲绉瀛缁蹇澶存★杩璁╄浜椤剁骇蹇瑕澧浼哄

褰讹涔拌杩涓寮绌跺骞寸瀛澹颁涓涓

寰╋缁缁澶у帮涓О缇わ瑰琚璁や负涓цヨ蹇琛绠＄剧绛存稿炽涓浜婵杩绉瀛崇存瀹ｇО缇ょ澶辫锛姣濡锛涓绉缁杩娈缂哄け锛浜杩浜剧

瓒ヨ澶绉瀛灏缇よ涓轰涓翠锛璁や负瀹汉浣瑕ㄥ瀹娈ㄨ寰╃澶х害100涓浜夸釜锛汉韩缁伴10浜轰瓒杩70%绮搴芥ㄨ锛杩浜搴涓戒渚璧浜伴澶х寰╋翠戒渚璧浜浜缁典唬璋骇┿

瀹缇ょ规锛瑰16S rRNA哄娴搴Metagenomics瀹哄缁娴搴ㄤ杩涓灞锛璁╀汉浠浠ユ村绌剁剧涓缇ょ崇郴

绁缁╁瀹讹浠灞版

杩澶х骞翠у颁绁缁╁棰

寰澶浼涓涓村绉拌濂借缇ゆ╀汉蹇绮剧ュ悍锛浣绁缁╁瀹舵绘搴や浠ラ蓟

锛磋版ョ锛绁缁郴缁剧璺澶ц绁缁郴缁筹缇ゅㄨ瀛锛瀹浠绯讳技涔病ｄ绱у锛

浣ㄦ瑕甯哥‘瀹板璇浣锛宸茬寮烘绉瀛楠璇〃绛涓缇ゅけ琛℃炽澶绉绫诲璺缇ゆ稿筹骞朵涓被寰芥缇ょ澶辫存

绁缁╁瀹跺ㄧ瀛楠寮烘璇涓锛姝ｅㄥュ板肩缇ょ澶ф涓2014骞达缇藉藉绮剧绌舵村ぉ板ㄧ绌跺井╁澶ц崇郴椤圭ヤ瓒杩涓句缇2014骞1119ワㄧ界缁╁骞翠涓锛绉瀛浠涓ㄥ璧蜂涓涓寰╁澶ц锛绁缁瀛歌杞Щ

歌杞Щ锛拌涓灏@#$%^&*浜锛ユ锛锛搴ヤ涓涓锛杩瑙ｉ规戒锛杩涓璇ㄦユ堪ㄧ瀛撮锛涓绉ㄥ烘璁轰瀵规规璁剧瑰杩绉瑰锛ヤ害搴ㄦ煎绉朵瀛归㈢宸ㄥぇ杞

灏辨锛绁缁╁瀹朵滑浠瑕寸板虫敞缇や锛璇翠澶╋绁缁涓锛浠ョㄧユ不

2010骞达ㄤｈ灏辫杩浜6700涓浜猴锛涓借ｈ借杩1000涓浜猴朵腑0-14宀ｅ垮借杩200涓浜恒缁杩浜ｈ繁瀹朵汉甯ラ挎娌娲汇缁绮剧

绉瀛锛1锛哄绐寮璧锋浜瑰哄澶э2锛哄琛ㄨ揪剁琛ㄨ浼寮锛3锛澧姹℃锛4锛姣浜叉瀛寸浣锛5锛＄锛6锛浠ｈ阿介纰锛7锛寮甯革8锛澶ц杩澶辫　锛9锛姘у搴婵搴锛10锛绾跨浣介纰锛11锛茶绋涓绁缁

惰锛ㄦ杩浜绱涓存浜浠舵涓瑕璁ㄧ

涓剧

浠绮绘板伴╀腑寰┿╁杩烘锛涓涓灏灏变婵璧疯韩浣搴锛虫缁灞涓虹寰澶чㄥ跨涔楗卞规郴圭㈡т究绉椋绠¤娴绛剧涔ㄤ浠锛藉瑙瀵拌ㄥ甯稿娓澧

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涓缇

瓒ヨ澶璇缇ょ缁涓釜浣琛涓虹稿筹瑰ㄨｈ涓浣濡涓杩帮绉瀛浠寮濮浜瑙ｈ缁褰卞澶ц

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涓扮胯缇

绉瀛浠锛寰╂ㄥㄧ╁茬╂瀵瑰ぇ蹭骇澶х褰卞ㄥ璇楠涓绉瀛锛逛骇灏姣堕『浜х灏翠负骞惰借瀵版讹瀹浠缇ゅㄤ涓枫逛骇灏锛ㄧ浜ц绋涓娉寰姣榧撮涓缁杩瀹娈ㄥ浠锛藉奖缁韬绮剧ュ悍

涓浜绌惰〃姣浜插ㄥ涓ラ锛瀛╁锋ｈ宸ㄥぇ椋╋琚浣姣浜茬涓ョ瀛╁缇ゅ浜锛瑰ㄦ翠娇ㄤ绱濡濡锛濂逛滑藉姝ゅ甫缁繁瀛╁涓绮剧娈俱

杩瀵规涔冲荤绌讹姣涔冲荤濠村跨缇ゆ╀ぇ层杩涓哄跺戒板绱风垮瀛IGF筹IGF涓┐胯缁姝ｅ父垮茬稿宠锛朵涓绉╂蹇姣涔充腑瀵¤绯淇杩浜濠村胯缇ょ裤

缇ょ绌跺甫缁甯

2013骞达缇藉宸宸ュMazmanian瀹楠瀹ょ绌朵汉PaulPatterson浜浠锛ㄤ浜剁灏锛寮辨姣姝ｅ父灏浣澶锛杩浜灏琛ㄧ寰翠负绱у绀句氦у苟涓剧躲浠や汉杩浜灏椋寮辨锛绔跺杞讹

浠浠磋涓姝ョ绌跺锛ㄦ剁灏琛娑蹭腑浜甯搁姘村钩4-ethylphenylsulphate (4EPS)4EPS娉ㄥュ版甯稿浣浜杩浜灏躲杩浜绌剁哄惰涓瑰‘锛绉瀛ㄥ画绌朵腑锛娉ㄥ4EPS寮璧蜂婕娴瀹藉氨姝ら杩澹杩ュ拌韩浣涓ㄤ褰㈡

杩缁娌荤浜虹渚浜芥эユ浠浠ュ烘伴锛浣ㄤ锛瑰х烘濡寮辨绛匡舵娑4EPS绛浠ｈ阿浜х╋杩缂瑙ｇ虫不

浜轰滑兼板绌惰藉敖蹇绐达浠ラ绂村蹇绮剧ｈ锛涓烘锛杩涓ㄥ杈浜扮绌堕锛Nutritional Psychologyュ诲瀛

褰讹浠娓斤界跺凡缁浜绉瀛绌朵宸ㄥぇ杩姝ワ浠涔浜村璁よ锛瑕褰诲棰插娌绘锛杩婕跨璺璧般灏卞缇ゆ浣褰卞浠搴绮剧舵锛浠瑕村绉瀛涓绱

Gut microbes and the brain: paradigm shift in neuroscience.  J Neurosci.  2014 Nov 12;34(46):15490-6

Mental Health: Thinking from the Gut. Nature 518, S12S15 (26 February 2015)

Microbiota Modulate Behavioraland Physiological Abnormalities Associated with Neurodevelopmental Disorders. Cell. Volume 155, Issue 7, p14511463,19 December 2013

Gutbrain link grabs neuroscientists. Nature 515, 175177 (13 November 2014)

Autism and Our Intestinal Microbiota. J Mol Microbiol Biotechnol . 2015;25:5155