绔绉涓轰涔瀹规缁斤

ㄤ缁涓绉澶╂涓蹭激瀛ｈ妤杈路涔杈┿插锛绉涔涓烘涔хㄦ借琛扳涓茬甯镐瀹惧勾澶诲绂归＄㈢插瀵モ存茬负浜虹浼缁浠ユ茬涓洪璇存ㄥ帮蜂惧害剧茬璇°

浣澶╀惰瀛ｈや茬锛浠绉浠氨涓绂杩风浜锛板叉浠ｆ浜虹涓绉楂绾р锛杩浜洪戒琚奖锛瑕绛杩涓锛介杩璋ュ浜轰滑ㄧ瀛ｇ缁舵ヤ瑙ｃ

浜瀹涓锛藉绌跺浜轰滑ㄤ瀛ｈ缁‘瀹杩琛杩涓浜璋ワｄ浠ョㄧ瀛ｏ浜轰滑缁枫涓杩瑕虹璇涓充测堪锛村板浜瀛绮剧瀛绌朵腑缁

绉瀛ｆ缁濮宸

1991骞达缇芥灏归寰烽绌舵锛WalterReed Army Institute of Research锛绌惰缃妫Leora N. Rosen锛瀵圭界撼锛Nashua锛椤裤绾界害ㄦ绱㈠锛Sarasota锛缇借タㄥ锛涓绾害1671灞姘杩琛浜欢璋ワ缁剧ず锛浜轰滑ㄥ炬浠ュ浣澧锛浣涔ㄧ瀛ｄ浜烘瑙[1]浠浠绌朵腑涔ュ锛杩涓ㄥ浜哄ㄧ瀛ｆ瑙濂姐ㄨ涓ヤ腑锛浠娉ゆ汉浠ㄧ瀛ｉ锛缁虹涓存х

1996骞村2000骞达绌惰瀵瑰诲㈠插㈢瀛杩琛浜璋ャ浠浠缁ョ锛71锛ュ宸浜烘版澶[2]

杩锛╁界璋ヨ浜2015骞2ㄣ缁煎绮剧瀛锛Comprehensive Psychiatry锛蹇琛ㄧ绔剧ず锛552璋ョ╁戒汉涓朵腑41.6%浜鸿〃绀哄瑙宸38.2%浜鸿〃绀哄瑙宸[3]浣缁瑙瀵浠浠缁锛跺ュ瑙宸浜烘版澶18浠斤瑙涓撅缁煎涓╀袱界绌讹浠浠ュ锛78涓ゆ芥澶浜烘瑙蹇宸涓や釜锛杩涓ゆ姝ｅ浜浜ゆ夸

瀹涓锛瀛ｈ瀵规缁奖杩涓姝㈡缁娉㈠杩藉涓绉涓村涓锛瀛ｈф纰锛Seasonalaffective disorder锛绮剧瀛瀵硅绉堪绉澶浣锛ュ舵跺ㄧ瑙ｆㄥ杞涓鸿[4]浠涓逛ョ锛绉瀛ｅ藉奖涓浣芥蹭激锛

澶缁樊锛绉澶锛杩负浠涔

缁缁璐

ㄧ瑙ｇ瀛ｄ缁界崇郴涔锛浠浜瑙ｄ涓缁

缁浠韬锛ぇ锛瀵瑰浜╃涓绉搴缁浜х锛川涓缁郴缁涓锛浠绁缁郴缁辨颁互浜胯绁缁缁锛褰㈡浜涓涓绯荤杩浜绁缁灏ゅ杩浜缃缃绾夸凤灏韬ㄥ淇″浼瀵煎颁腑澶ュ澶ц锛朵灏澶ц浠や杈板涓ㄥ

惰锛浠绁缁骞朵绾らｆ凤涓涓灏卞浠ョ存杩淇″璧风瑰缁广稿锛绁缁郴缁瑕灏淇″浠涓ㄤ锛姣濡澶ц锛浼板涓涓ㄤ锛姣濡锛锛瑕杩澶涓缁缁绁缁绁缁氦缁存ヨ琛淇″浼绁缁浠杩ㄥ涓凤涓涓涓涓淇″浼涓姝ｅ璧璺瑕妫涓凤绁缁ㄧ镐浼淇″讹瑕涓浜淇＄╋杩浜淇＄╂浜规瀛╄川绁缁璐ㄣ绁缁璐ㄧ藉绉澶凤璇涓涓涓缁蹇瑰村璧锋ワ淇″缁х画浼涓锛涓涓涓缁淇烽锛涓瑕浼淇″浜杩浜绁缁璐ㄧ姝ｅ父杩浣锛璁╂翠釜绁缁郴缁ㄤ璧锋ャ

ㄨ浜澶风绁缁璐ㄤ腑锛绉涓缁瑰稿筹5-缇茶猴涔琛娓绱锛serotonin锛澶宸磋猴dopamine锛绫婚跨╄川锛opioid锛绛朵腑锛澶ц涓5-缇茶虹骞宠　涓缁甯稿崇郴界舵浠浠朵界瑙ｅぇ5-缇茶烘按骞充朵寸崇郴锛浣浜╁浠ユ瑰澶ц5-缇茶烘按骞筹缂瑙ｆ躲澶ц涓宸磋哄绫婚跨╄川涓蹇绛绉缁绯荤揣瀵锛姘цㄥ澶宸磋虹姘村钩锛璁╀瑙寰寮蹇

ョ濡浣瀵艰存缁锛

绔绉涔剧灏辨藉ぉ娓缂╃澶堕村裤杩绉ф堕寸锛汉浠缁筹浠璋ユョ锛ф堕翠汉浠宸缁妯″涓瀹绯伙ф堕存跨浠斤涔缁宸浠斤ф堕存浠斤蜂缁樊堕存[2]浠绉崇郴锛浠ユф堕撮瀹芥濂藉

㈢舵缁富瑕涓ぇ涓绁缁璐ㄦ按骞虫筹ｅョф堕寸甯告瑰浜轰滑绁缁璐ㄦ按骞虫ユ瑰缁浠绌舵ョ锛纭姝ゃ

2002骞达婢冲ぇ╀绌惰颁集癸GW Lambert锛绛瀵101ュ悍锋ц琛瀹琛锛杩琛娑叉ラ存版楠浠浠澶ц涓5-缇茶哄浠浠ф堕磋匡5-缇茶哄楂锛ㄥ讹5-缇茶哄浣[5]ヨ垮ぇ澶浼澶у绌惰杩涓姝ヨ瀹浜杩涓璁[6]界跺ぇ5-缇茶哄涔寸崇郴浠朵涓虹绌惰浠瑙ｏ浣复搴荤锛浠ヤ娇ㄥユ不瀛ｈф涓杩瑕灏ф堕磋匡涔借浜哄涓濂姐

涓杩锛瀵逛浣ㄥ涓板浜烘ヨ锛ф堕翠樊涓澶锛浣舵浜哄ョ缁斤浜虹缁娑ㄣ杩绉浜轰汉涔寸宸э芥浼绱炽2003骞翠椤瑰琛ㄥㄣ瀛绮剧瀛锛Molecular Psychiatry锛涓绌跺锛涓澶朵绮剧剧崇哄5缇茶鸿浆杩浣哄澶э5-HTTLPR锛纭涓ф纰稿[7]涔灏辨锛浣缁板褰卞锛戒ㄥ板哄褰卞

瀹璇绌讹浼间浠ｆ浜哄浜绉测涓锛澶芥缁宸跺规浜绌舵ラ娴锛浣涓轰骞达浣78浠芥缁宸姒杈澶э浣ㄦ绉惰锛蹇芥杈濂界濡浣洪骞达ｅ氨涓濂借浜浣澶杩涓瀹绀烘浠绉瀛ｅ芥缁寮绔瑕濂介插伐浣锛垮ㄥ轰弗

PS锛瀵逛锛涓涓璐硅娉灏辨澧ф堕达澶澶筹杩涓规芥╀ㄧ缁存5-缇茶哄骞宠　锛垮浜х

璧

[1] Rosen, LN, Rosenthal, NE. Seasonalvariations in mood and behavior in the general population: A factor-analyticapproach. Psychiatry Research 1991; 38(3): 271-283.

[2] Han, L,Wang, K, Cheng, Y et al. Summer andwinter patterns of seasonality in chinese college students: A replication.Comprehensive Psychiatry 2000; 41(1): 57-62.

[3] Baek, JH,Kim, JS, Huh, I et al. Prevalence,behavioral manifestations and associated individual and climatic factors ofseasonality in the korean general population. Comprehensive Psychiatry 2015;57: 148-154.

[4] 楂瀹姘, 冲娉, 娓╃. 瀛ｈф纰. 涓藉蹇 1999; (06):379-380.

[5] Lambert, GW,Reid, C, Kaye, DM et al. Effect ofsunlight and season on serotonin turnover in the brain. The Lancet 2002;360(9348): 1840-1842.

[6] Praschak-Rieder,N, Willeit, M, Wilson, AA et al.Seasonal variation in human brain serotonin transporter binding. Archives ofGeneral Psychiatry 2008; 65(9): 1072-1078.

[7] Willeit, M,Praschak-Rieder, N, Neumeister, A et al.A polymorphism (5-httlpr) in the serotonin transporter promoter gene isassociated with dsm-iv depression subtypes in seasonal affective disorder. MolPsychiatry 2003; 8(11): 942-946.