ㄨ绮ユ风‖锛绌剁澶锛

哄锛绉瀛ぇ

浣锛癸涓界瀛娴风界瀛绌堕  灏规у锛涓界瀛娴风界瀛绌堕

讹涓界瀛㈣绠虹缁淇℃腑蹇涓界瑙

娲绘按骞崇楂锛瀵璐电娓璧板ユ浠瑙绾裤

浜轰滑甯歌瀵璐电浠ョ浠ｈ阿绱涔变负虹浠ｈ阿剧锛浠澶╂浠虫敞朵腑涓绉ㄨ绮ユ风‖

浠父璇寸ㄨ绮ユ风‖锛跺浜ㄨ纭涓绉锛杩绉蹇琛绠＄郴缁涓父瑙瀵璐电甯镐互涓骞存ｈ灞澶锛浣变娲绘按骞崇楂锛濡浠ㄤ浜澹勾涓浼虹

ㄨ绮ユ风‖绌剁涔

跺锛ㄨ绮ユ风‖绉辫璐ㄣ洪朵╄川缁ㄨ绠″褰㈡寮璧风㈡х剧

ㄨ绮ユ风‖娓褰㈡杩绋

ㄨ绮ユ风‖灞涓婕跨杩绋锛浠ヤ富瑕涓轰互涓涓舵锛1锛╂澧绾瑰舰锛2锛绾ょ淮锛3锛涓绋冲锛4锛磋浜х琛锛浠诲琛绠★褰卞渚琛

变ㄨ绮ユ风‖涓琛ㄧ轰复搴讹瀹规琚拷瑙锛浣褰浜х涓ラ诲瀹ㄩ诲琛绠℃讹灏变璇卞涓ラ蹇琛绠＄剧锛跺ㄨ剧锛棰ㄨ剧浠ュ澶ㄨ绠＄剧

ㄨ绮ユ风‖浜浼凤

浠ラ锛ㄨ甯浜轰澶锛浠ヤ汉浣涓ㄤㄨ戒姐褰讹杩朵腑涔归ㄤ锛虫村涓ラㄨ绮ユ风‖版癸姣濡锛涓诲ㄨ跺ㄨ棰ㄨㄨ惧ㄨ绛

ｄ锛ㄨ绮ユ风‖浜浼甯ュ藉卞锛

戒锛ㄨ

变播锋村姝ｅ父琛绠″锛瀵艰磋绠″垮瑰锛琚杩涓杈硅绠″锛琛绠″朵涓烘ュ甸璧蜂涓锛濂藉堕戒稿涓凤寰藉舰ㄨゃ

宸姝ｅ父逛富ㄨ锛锛ㄨょ惰逛富ㄨ锛剧ユ锛缇ワ

ㄨゆ变ㄨ绠″寮辫涓绉姘镐ц胯剧锛ㄤ换浣ㄤ芥藉舰

涓杩锛ㄨゆ甯歌骞朵楹荤ㄤ锛ㄨㄨ锛涓诲ㄨ锛浠ュ蹇车虹琛娑插甫寰韬朵ㄥ澶уㄨ

绠ご蹇瀹ゅㄨわ浣浜甯歌瀹ゅ涓锛剧ユ锛瀛帮

戒锛跺ㄨ剧

跺ㄨ剧锛宸茬涓虹姝讳骸楂剧涔涓

涓哄跺ㄨ负浠蹇渚琛锛涓虹靛灏变瀵艰村缂鸿锛蹇缂鸿藉璧峰缁锛涓ラ渚琛涓氨浼瀵艰村姊姝伙璇卞姝讳骸

绮ョょ榛瑜叉浣垮跺ㄨ剧锛骞朵琛瀹ㄩ诲浜绠¤锛剧ユ锛瀛帮

跺ㄨ绮ユ风‖涓昏ㄥ跺ㄨ涓褰㈡锛甯镐即跺ㄨ锛浣垮绠¤绋搴э冲翠琛涓寮璧峰缂鸿稿蹇锛骞跺涓哄婧х姝荤

戒锛涓诲ㄨ澶瑰

ㄨ绮ユ风‖瀵艰磋琚靛锛琚靛琛娑插涓烘ㄥ氨浼ㄨ澹灞达涓诲ㄨ磋锛琛娑插ㄥ浣ㄤ茶涓诲ㄨ澹澶╁锛杩峰氨褰㈡浜涓诲ㄨ澶瑰

涓诲ㄨ绉颁负锛涓诲ㄨ涓瑁寮褰㈡涓哄锛涔存涓涓颁釜村搁锛剧ユ锛缇ュ悍崇变腑蹇㈡хヨ搴锛

涓诲ㄨ澶瑰绉堕╃蹇琛绠＄剧锛变绋甯稿揩锛澶版ｈ3澶╁灏变琛绠＄磋姝讳骸锛涔姝わ瀹涓烘ｈ浣涓瀹剁稿脊

褰讹涓ㄨ绮ユ风‖浼寮璧蜂富ㄨ澶瑰锛楂琛濡濞浼绱锛椹＄患锛涓诲ㄨ澹涓涓诲ㄨ绮ユ风‖涓诲ㄨх剧澶浼ょ锛芥富ㄨ澶瑰遍╁绱

朵

や浠ヤ剧锛ㄨ绮ユ风‖杩藉棰ㄨ剧锛变奖浜瀵瑰ぇ渚琛锛瀵艰翠腑椋

跺澶ㄨ绠＄剧村琚拷瑙锛涓昏褰卞涓寮璧疯璧扮涓肩

ㄨ绮ユ风‖棰蹭不

璇卞ㄨ绮ユ风‖椋╁绱涓昏琛寮甯哥洪姘村钩哥绯灏跨ヨ绛

绌惰〃浠浠ラ杩ㄥュ悍娲绘瑰ユ剁稿崇椋╁绱锛棰叉寤剁ㄨ绮ユ风‖浠ュ稿崇剧锛涓昏锛杩ㄤ互琛￠ギ椋

姝ゅ锛ㄨ绮ユ风‖浠ヨ琛╂不不锛不ㄤユф涓ラ琛绠＄锛涓昏跺ㄨ浠ユ不锛PCI锛锛跺ㄨˉ锛CABG锛浠ュ棰ㄨゆ

杩骞存ワ绉浜哄ㄥㄨ绮ユ风‖褰㈡哄舵归㈠寰浜绐存х杩灞锛杩浜绌舵瀵归插娌荤ㄨ绮ユ风‖锋瑕诲浠峰笺

绌朵璇琛娴ㄥ瀛ㄥㄨ绮ユ风‖灞杩绋涓瑕浣骞朵负ㄨ绮ユ风‖娌荤渚浜扮舵

杩涔绌跺锛骞撮澧匡界绐藉村琛绠＄剧锛杩棣娆℃绀轰骞撮绱涓琛绠＄剧稿虫с

姝ゅ锛涓界瀛娴风界瀛绌堕㈡杩涓椤圭绌惰锛浣搴斤LDL锛琛ㄩ㈢纾疯姘у浜х╀腑瀛ㄤ绫绘姘у浣ㄧ板浠ｈ阿╋杩浼间缁璁や负LDL姘у淇杩ㄨ绮ユ风‖瑙规浜茬锛浣涔芥轰浠ｅ挎у搴

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2.McGill, H. C., McMahan, A., and Gidding, S. S. (2008) Preventing heart disease in the 21st century implications of the pathobiological determinants of atherosclerosis in youth (PDAY) study. Circulation 117, 1216-1227

3.Wang, L., Luo, J. Y., Li, B. C., Tian, X. Y., Chen, L. J., Huang, Y. H., Liu, J., Deng, D., Lau, C. W., Wan, S., Ai, D., Mak, K. L. K., Tong, K. K., Kwan, K. M., Wang, N. P., Chiu, J. J., Zhu, Y., and Huang, Y. (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540, 579-582

4.Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C. L., Sano, S., Muralidharan, S., Rius, C., Vuong, J., Jacob, S., Muralidhar, V., Robertson, A. A., Cooper, M. A., Andres, V., Hirschi, K. K., Martin, K. A., and Walsh, K. (2017) Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 355, 842-847

5.Lu, J., Guo, S., Xue, X., Chen, Q., Ge, J., Zhuo, Y., Zhong, H., Chen, B., Zhao, M., Han, W., Suzuki, T., Zhu, M., Xia, L., Schneider, C., Blackwell, T. S., Porter, N. A., Zheng, L., Tsimikas, S., and Yin, H. (2017) Identification of a Novel Series of Anti-inflammatory and Anti-oxidative Phospholipid Oxidation Products Containing Cyclopentenone Moiety in vitro and in vivo: Implication in Atherosclerosis. Journal of Biological Chemistry (in press).

锛绔棣浜瀛ぇ涓娴风绉绋匡