楗辫藉欢骞寸瀵垮锛

浜虹被灞锛瀵逛ぇ澶颁汉ヨ╁凡涓浠堕瑕浜稿锛寰杩澶浜锛ヨ锛绯灏跨绛瀵璐电寮濮璧板ュ甯哥惧瀹躲惰跺帮涓轰杩芥ュ悍锛澶у寮濮虫敞澶灏锛濡浣㈢跺澶浜涓ソ浜锛ｄ涓瑰夸涓浼ュ荤锛寤跺勾瀵跨瑰

跺杩涓虫ㄤ袱澶骞村绉氨宸茬浜搴瀛路ユ父浜濮灏涔灞憋绁浜哄よュ伴娣绾ュ瀛锛涓椋浜璋凤搁ギ诧涔浜姘锛寰￠榫锛娓镐娴蜂澶瀹剁涓椋浜璋封姝ｆ腑戒缁荤娈碘杈璋封ユ涓藉涓璺浜轰慨尖杈璋封璁拌浇姣姣涓ㄨ涓惧勾

瀵光杈璋封瑙ｏ涓藉お绠涓椋浜璋封涔浠浠浜涓婚锛涔灏辨⒊姘村╋ワ朵绫诲椋╄杩姝ｆ涓缁椋骞翠锛澶╀汉芥轰杩1981骞寸卞板卞ュ褰剁卞介搁濞瀛灏澶汉姘板锛褰诲缁椋锛澶澶╀椿娲婚タ姝汇璋涔涓虫拨藉拌涔叉ㄧ澧版锛浠ュ变滑璁ㄨ杈璋封纭拌椋锛涔灏辨ㄤ瀹绋搴剁ワ涓ユ灏ャ

榧椋藉瀵

ｄ椋板戒ュ荤锛寤跺勾瀵垮瑕纭绛杩涓缁浜姘磋蕉浜锛涓汉缁涓哄绉绱褰卞锛寰寰涓瓒充互浣涓轰ュ烘句娴疯缁璁恒瑕寰鸿风缁璁猴蹇椤讳涓ユ艰璁°瓒冲锋伴瀹楠涓炬宠薄锛ㄤ汉涓哄璞″杩风瀹楠跺伴剧杩借釜澶ч汉缇らギ椋涔苟瀵瑰界褰卞锛璺ㄦユ涔锛绉骞叉板绱寰句涓ゃ涓杩濂藉ㄦ浠瓒崇瀹楠ㄧ╋榧

涓哄轰钩ㄧ╋榧绻娈藉寮猴瀵垮界涓ゅ勾宸锛锛姝ｉ璁╂浠ユ楠涓涓椋欢骞寸瀵裤╁ㄤ涓绾30骞翠唬锛绉瀛灏卞凡缁椋榧姣澶╁ぉ浜╅榧瑕娲诲涔姝ゅ板骞达绫讳技璞¤澶瑙瀵般

浠澶╁变滑灏辩涓涓浠ｈ〃х绌躲1986骞达宸澶у娲跺＄绉浜哄浜杩涔涓涓楠1锛浠浠挎绮剧‘朵榧ョ浠ユヨ╅85锛5040℃涓轰淇璇榧ュ诲琛★剁椋璋卞舵敞ˉ浜缁寸绱寰绱锛锛惰韪榧瀵垮藉朵涓浜瀹楠缁绠存涓浠や汉淇℃锛寰瓒灏榧韬瓒″戒瓒匡1锛锛涓浠濡姝わ灏榧缃规ｄ浜跨ょ姣渚涓浜锛涓浜郴缁界捐楂

界垛杈璋封ㄨ榧韬寰浜‘锛榧姣绔涓汉锛缁蹇璇昏涔璁稿凡缁锛灏辩椋缁涓垮锛涔娲讳骞村锛杩跺宸茬寰浜浜锛涓轰榧涓ゅ勾涔灏辨浜锛锛杩澶у姝ｅ冲瀵硅薄锛浜虹被锛杩稿澶х宸浜瀹涓锛界惰榧浜哄涓哄轰钩ㄧ╋寰澶归㈤搴镐技锛浣绔璐ㄩ稿樊涓锛瀵艰磋川锛ㄨ榧韬炬涓瑗挎惧颁汉韬寰藉氨涓ｄ浜浜浠ユ宠榧瀹楠缁濂ㄥㄤ汉韬瑕

村椋存藉欢骞

ｄ锛娌℃姣榧存杩浜虹瀹楠ㄧ╁锛ｅ氨村ㄧ村韬妫楠杈璋封欢骞寸瀵块ｆ瑕涓稿澶у冲锛涓虹村芥椿涓澶骞达浣涓浠寰涓骞村涓ュ板纭涓澶х兢村椋锛杩寰淇璇ㄥ浠涔浣繁锛抽杩涓棰绔姣涓澹浠ヨ╄浆琛浜ㄥ姝ｇ妗寮虹濂藉蹇椹变娇涓锛缇戒袱瀹跺肩绉缁锛濞悍藉甸跨被绌朵腑蹇锛Wisconsin National Primate Research Center锛浠ヤ绠绉W瀹讹藉琛拌绌堕National Instituteon Aging锛浠ヤ绠绉N瀹讹浠涓绾骞翠唬濮浜婕跨寰绋锛跺寰芥村抽浠病杩瑗挎父璁般锛涓ラ涓澶骞村瀛绌哄凡缁寸被浠风姝荤翱涓浜锛濡浠浠楠杩琛颁绐舵浜哄璇浠浠涔瑕淇℃浠涓浼蹇宕╂锛涓绠℃璇达瀹楠寮濮浜锛涓ゅぇ缇ょ村╄浜虹被璧浜瀹浠瑕浣垮斤蹇板娲荤

堕寸浜ヤ21涓绾10骞翠唬锛村浠ぇ缁浜颁锛璧村户ラ锛肩绉浜哄浠缁浜哄ご浜2009骞村2011骞达W瀹跺N瀹跺ㄣ绉瀛躲涓ゅぇ椤剁骇蹇涓琛ㄤ缁2,3诲虹W瀹讹浠浠卞浜76达哄拌╅缁椋缁锛椋缁ヨ姣╅缁浣30%涓轰缁璁烘瀹涓鸿锛W瀹堕ㄥ板绀轰╅缁椋缁涓寸х锛2锛锛╅翠稿咖锛韬姣涓╁硅椋翠稿剁革韬姣娌瑰婊浜涓杩绉涓捐璇锛瀹ㄧ版褰垮烘ョ锛婕极浜浣骞翠腑锛椋缁讳瀛娲荤稿浜╅缁寰寮辩楂锛3锛

涓杩绉瀛浠剧朵蹇锛浠浠涓绉缁璁℃版规锛蹇琛绠＄剧锛绯灏跨杩绉宸茬ュ琛拌稿崇姝诲濡浜杩涓舵′欢璇锛ｄ椋缁灏辨╅缁浣轰杈涓烘剧浼挎ヤ涓杩杩涔甯ヤ涓涓锛濡讳姝讳骸澶ц寸稿浜涓“崇姝讳骸宸ｅ涓椋缁ㄦ浜归㈡╅缁浜锛㈠璇璇达涓逛姝昏タ规锛椋缁涓涓娉宸诧褰瑕浣涓村锛璋㈢浣颁达浠ワ杩浜版涓璇存╅缁椋缁瀵垮藉ぇ浣风锛浣ㄦ村涔锛╅缁撮姒缃规ｅ琛绠＄剧锛绯灏跨杩浜宸茬ョ涓“稿崇浜涔浜х浜涓涓锛娌″杩浜椋缁板姝荤瑕纭绛杩涓缁浜锛浜瀹涓W瀹剁绉浜哄涔骞舵惧姝や鸿璁恒

绱ч跺诲虹N瀹剁村浠N瀹舵病渚瀹浠村х锛涓ラN瀹舵杈瀹杩ㄦ涓轰村锛杩圭村瀹楠缁澶ц村W瀹舵寸锛4锛浠ワ浠浠ュ烘杈纭缁璁猴挎椋骞朵芥捐寤堕跨村瀵垮姐澶у杩涓浠ョ鸿界跺ㄨ榧韬椋浣轰绁濂垮锛浣㈠版存杩浜虹村韬璨浼煎氨涓澶х靛浜N瀹朵浜涓“崇剧涓W瀹剁涓N瀹惰缁村锛涓“稿崇姝讳骸ㄨ╅缁椋缁涔翠害烘捐宸

椋╀挎㈡х骞寸

椋戒藉瀵匡浣借浜猴村锛娲诲村ュ悍锛姣绔や姘ㄤ澶锛娲昏川瑕

や缁璁℃浜＄涔澶锛W瀹跺N瀹朵藉虫敞浜娲荤村浠椤规涓烘锛椋缁瑕姣╅缁捐拌★涓浣宸涓昏ヨ澶涓涓寒汉肩缁灏辨椋瀵圭灏跨澶锛W瀹跺楠锛╅38村涓16虹浜绯灏跨锛椋缁38灞舵涓涓锛椋缁村蹇涔涓浜涓N瀹剁瀹楠涔璇瀹浜杩浜缁ワ楗辨╀跨灏跨ヨ蹇琛绠＄剧绛㈡х骞寸

缁璇

虫锛浠ｄ汉荤瀵光杈璋封浜姣杈娓妤璁よ锛搴椋浠ユ瑰㈡х骞寸锛浠楂娲昏川浣瀵归垮炬瑕澶у涓圭ㄨ浜村瀹楠锛灏辩╅缁锛村夸滑涔ュ悍娓娣♀椋╋浠涔＄搁浮涔绫婚ｆ病锛存婊撮戒娌剧浠ワ杩浜瀹楠缁瀵逛璇澶у浠ユ惧″娴峰

锛浣锛捐锛娓ぇ瀛界瀛澹浣诲㈢╁澹

[1] Weindruch, R., Walford, R. L., Fligiel, S. & Guthrie, D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 116, 64154 (1986).

[2] Colman, R. et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (New York, N.Y.) 325,2014 (2009).

[3] Mattison, J. et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489,31821 (2012).