甯妫涓浠锛

绗娆＄ラ甯妫患(Parkinsonism)锛ㄩ灏钩涓跺褰舵杩釜涓锛杩涓涔椴ラ锛捣"涓

璇荤缁╁绌剁讹涓婚㈡昏灞锛轰瑙颁灏ユ荤甯妫ｈ锛寮濮㈡瑙ｈ涓

2012骞达璋锋濮浜轰涓Sergey Brin锛涓烘浜叉ｇ涓繁涔寰楂ｇ锛甯妫患娌荤绌舵烘璧宸ㄨ锛甯ㄨ繁涔诲娌绘鹃锛20052012骞村辨璧浜涓浜夸涓ょ句缇锛锛

褰舵涓绂ㄩ卞氨甯╄繁涔芥浜猴朵璧蜂磋叮瑕瀵瑰妫患涓绌剁

甯妫患涔锛

浜ュ璺浜哄垫讹姘寰瀵规规寰村杩稿茬瀵规瑰浜甯妫甯妫板涔锛灏辨锛

甯妫杩涓瀛ユ浜卞藉荤James Parkinson锛浠1817骞撮娆¤缁ラ浜ｈ跺灞杩绋锛浠411ヤ琚藉涓衡甯妫モ

甯妫患锛复搴涓ㄦュ涔涓绫昏ㄧ患姒蹇碉朵富瑕姝㈡堕琛ㄨ缂㈠韬电‖娉淇绋冲濮垮跨浠父甯稿扮甯妫(Parkinsons Disease,PD)锛灏辨绉缁煎甯歌涓绫汇

や棰ゆ锛浜鸿芥涓浜跺ㄤ琛涓轰琛ㄧ锛 濡㈤ㄨ〃电‖锛㈠疯糕锛ㄧ煎藉伴俱璇磋澹伴冲寮便╂姝ヨ蛋璺绛浜哄烘ョ瀛甯镐寰灏

甯妫患借瀹涔涓鸿ㄧ患锛浣涔甯稿父浼撮绮剧绫荤讹濡＄版帮澶寸＄澶姊ㄤ锛瑙纰锛濡瑙瑙瑙绌洪存涓锛璁ょラ纰锛濡娉ㄦ璁板琛伴锛绛

浠涔浜哄寰甯妫患姝ｅ澶у瀵光棰ゅ宸筹涓ｇ藉60宀浠ヤ锛澶х害惧涔渚╀40宀澶х害1%60宀浠ヤ浜烘甯妫惰锛宸茬ュ勾榫灏ｈ跺濡繁浜蹭汉虹浜澶涓杩扮讹璇风诲剧稿冲荤ㄨ璇妫ャ

涓轰涔浼寰甯妫

浼锛浼锛璇卞锛

缃涓涓锛灏辨绉绔璇磋枫ｆ风娲讳寰甯妫跺锛瀵瑰ぇㄥｈ锛杩娌℃介姣浜璁绌讹纭璁ゅ妫涓浜绌惰〃绀鸿ㄦ浼わ浠ュ姹℃浼澧ｇ浣讳ヨ锛浠涓娓妤板杩涓

涓瑰浠ヨ锛瀹舵浼澧ｇ绌惰〃ぇ绾惧涔浜浠ヤｈ哄甫稿崇绐哄濡浠璺甯妫稿崇哄涓涓朵腑遍╂ф楂灏辨胺姝濮浜Sergey Brin浠濡濡哄甫绐LRRK2濡寸郴浜插琚‘璇甯妫锛浠ュ涓汉哄缁娴搴ヤ涓哄甫宸茬ョ杩浜遍╂у哄绐

ㄦ杈纭俊甯妫涓昏瑰ぇ涓涓ㄤ锛榛璐ㄨ村(substantia nigra pars compacta)涓宸磋虹缁姝讳骸杩浜绁缁涓浜惰ㄥ界瑕ㄤ瀵崇郴锛瀹浠姝讳骸瀵艰村ぇ涓浜绁缁稿㈢绯诲跺板奖锛缁绉杩ㄦ归㈢躲

澶宸磋虹缁姝讳骸哄惰ㄧ绌跺涓绉璇翠腑绌跺澶瀵alpha-synuclein界姝ｅ父绉杩浜藉ㄧ缁绉舰璺姘(lewy body)妫涓涓瑰锛涔妫妫ュ瑕璺姘甯告虹ㄥ瑙绯荤锛跺姝ヨ寤跺跺猴ジ澶ц惰锛璺姘绌剁缁姝讳骸缃绁搁锛瀹锛浣寤剁锛绉瀛杩ㄥ剧妗

甯妫浠ユ不锛

寰撅寰澶跺绁缁琛х剧涓凤甯妫杩娌℃娌绘广┿缁煎ф不浠ヤ瀹绋搴缂瑙ｇ讹浣娉杞姝㈢灞浠涓璇达娌荤规锛杩璇寸娌荤锛瑙ｇ讹芥负浜存存楂澶ц澶宸磋烘浠ｆ挎楂澶宸磋虹斤浠ヨˉ垮宸磋虹缁姝讳骸甯ョ澶便

╂甯妫娌荤杩ㄧ娉锛杩╂涓诲ㄨ濡㈤ㄨ〃宠娲诲ㄣ骞宠　绛锛烘榛璐ㄤ腑瀛澶宸磋虹缁锛澧澶宸磋哄娉

杩骞达娌荤甯妫╂寰澶绉锛澶чㄥ涔存存楂澶宸磋哄姐

宸澶宸(Levodopa)澶瑰乏澶宸存娌荤甯妫┿杩绉╄界┛杩琛灞锛ㄨ杞澶宸磋恒惰变灏ㄥ╃┛杩琛灞拌揪猴澶чㄥ宸澶宸村ㄥ杞寸郴缁杞㈡浜澶宸磋猴姝や剧ㄥ澶寸跺绛锛涓挎ㄦ不涔浼浣

澶宸磋哄浣婵ㄥ(Dopamine agonist)杩绫昏╅杩妯℃锛夸唬澶宸磋哄ㄤ借杈惧版不

跺╄浜瑰剁跺锛浣澶宸磋虹浠ｈ阿

姝ゅ锛杩涓绫讳富瑕╂纰辫借╋㈠澶宸磋哄涔拌纰卞ㄧ汗朵涓骞宠　锛瀵归姝㈡堕㈣函浣电‖姣杈

绫昏╁涓典ｈ涓ㄣㄤ涔瑕涓涓荤ㄧ郴缁璇浜寤鸿瀵笺

や╋涔ㄥ甯╁妫ｈ棰ゆ澶璁惧锛姣濡甯椹揪借ㄧǔ瀹哄椁枫朵腑涓瀹跺寰浜璋锋涓绗涓灏椋╂璧

ㄧ藉ぇ绾涓句琚‘璇甯妫ｈ锛淇瀹浼拌ㄤ澶х害涓涓甯妫ｈ锛杩浜板杩浠ユ勾涓涓搴ㄥ瓒ヨ澶烘缁缁涓汉寮濮虫敞杩涓兢浣やㄦ不归㈢ワ濡浣楂ｈュ父娲荤璐ㄩ寮濮涓哄虫敞癸濡やゃ楗ュ悍蹇缁存ゅ琛ㄤゆ归

板勾Liftware轰哄(anti-shaking spoon)锛杩涓骇界ǔ瀹哄澶уぇ浣甯妫ｈ繁杩椋伴俱

绫讳技界浜у杩2014骞Red Dot Award璁捐绔璧涓浠ヨ60澶涓藉4791浠戒涓遍虹(anti-shaking bracelet)杩涓璁＄娲杩娴ｆㄧ棰寮哄害锛骞跺虹稿瀵规浠杈惧板钩琛＄ǔ瀹

娌绘骞寸缁瑰

甯妫娌荤缁瑰锛姝诲绁缁琛ヤ涓疯ˉ涓

濡璇达甯妫绉涓哄ぇ绁缁姝讳骸剧涓绫讳技杩垮ㄦ捣榛锛淇绉扳骞寸村锛涓哄卞圭癸瀹浠借绉颁负绁缁琛х剧锛澶ф灏辨绁缁锛杩涓ょ锛璁稿镐技癸浣涔寰涓绠ユ杈濡涓琛ㄣ

锛寰撅绉瀛娉杞缁姝讳骸锛涔娉姝㈡浣绁缁缁х画姝讳骸浠ワ杩涓ょ剧娌荤藉界瑙ｉㄥ讹涓芥规娌绘姝㈢灞锛缃涓绉涓璋辩绁濂娌绘规锛剧跺藉靛典锛

ｄ锛娌绘杩绁缁剧缁规涔舵琛拌澶ц琛ュュ悍绁缁濡浣板璁轰涓ょ娉锛杩澶妞ワ烘澶цㄧ缁

璇寸涓绉规瀵瑰妫锛绁缁绉绘瀹楠╁ㄥ骞村灏辨浜哄ㄥㄧ╅灏璇锛浣涓哄绉锛杩灞缂姣绔锛绉绘涓规介撅浣电Щ妞澶绮惧阀涔绁缁绁缁缁

杩骞达浜轰骞茬寰浜绐椋杩虹杩灞炬涓绉瀛榛浠ㄤ璇锛杩ㄨ浜版ュ诲

璇寸浜绉规婵娲诲ぇ韩绁缁锛adult neurogenesis锛锛浠澶цㄤ负繁渚扮ュ悍绁缁锛涔绌剁涓涓瑰浜虹澶цㄨ濠村挎舵锛绁缁娲昏锛澶ц淇ˉ娼寰楂锛浣涓颁骞达杩浜绁濂灏卞

锛绉瀛滑宸茬ラ浜涓浜淇杩荤绁缁瀛哄讹姝ｅㄥ娣卞ヤ瑙ｅぇ濂ョ甯涓涔灏ワ藉惧扳典腹濡锛璁╁句浜哄纾ㄧ澶ц杩ヤ锛

(缁V缁垮miffyy缂杈)

璧

1.Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease. Mov. Disord. 2008 (S3), S548-59.

2.Missing pieces in the Parkinson's disease puzzle". Nat. Med. 2010, 16 (6): 65361.

3.Aldult neurogenesis and neurodegenerative diseases. Cold Spring Harb Perspect Biol 2015;7:a021287

4.http://www.parkinson.org

濂灏ャㄦ锋璐逛ワ甯╃惧害硅浜у浣楠锛杩轰寰惧害绾康涓