哥涓哥锛虹涓蜂锛

哥瀹冲ュ悍锛涓昏涓哄哥浼澶уぇ澧寰虹姒锛杩规搴哥疆璁虹峰コ锛璁轰腑缇虹芥涓浠涓璁╃绗90%虹ｈ芥哥锛锋у哥ｈ虹哥23锛濂虫ф13涓轰斤哥涔肩

浜涔浼澶ч虹锛浠ヨ寮虹卞烘绂璇ョ锛涓瀛锛褰瑰板锛芥辩姣勾缁垮涓澶ч╃垮浠朵腑轰ㄥユ卞ュ悍浜涓锛澶у涓磋寰垮夸寰剁绋ユ绌跺娌荤锛涓濂界锛涔濂浜涔涓

哥瀹筹浣剧跺哥虹骞朵藉绛锛哥涓涓瀹寰虹锛涓哥涔戒寰虹涓绱缁煎浣ㄧ缁锛锛澶锛杩杩姘锛哥朵腑涓涓瑕绱灏跺稿煎芥舵佃堕达缁杩5骞寸骇灏卞甫涓浜奸锛澹ｄ釜澶╁ぉ辩佃娓告瀹朵肩翠撮芥2.0锛跺娲荤寰濂

哥锛涓哥芥藉虹锛ｄ涓や釜绉瀛ヤ锛

1. 哥锛涓哥锛寰涓蜂锛

2. 哥锛涓哥锛浜烘不瑰娌荤涓蜂锛

绛绗涓锛绛妗涓涓枫界惰〃㈢璧锋ョ镐技锛哥虹涓哥虹ㄥ哄姘村钩宸ㄥぇ宸

杩绉宸冲琛ㄧㄤ袱涓归

涓哥虹哄绱涔辩搴杩瓒杩涓哥

绾〃㈡惧井涓ョ锛哥涓哥虹峰璧锋ュ介藉樊涓澶锛芥涓剁缁ㄩ璇堕达璇扮圭裤浣杩骞村哄娴搴杩姝ワ璁╂浠涓娆¤藉ㄥ井瑙瀛姘村钩瀵逛釜浣杩琛锛绗娆＄姝ｅ颁瑙ｆ涓川涓

浠ㄩ界ラ哄绐浜х╋姣釜缁芥澶涓哄绐锛浣互浠浜虹ラ哥哄绐板娌℃浠涔宠杩涓绡绌惰绗娆＄郴缁у瀵规浜哥涓哥虹DNA锛浜浠や汉缁璁猴界剁琛ㄩ㈢璧锋ョ镐技锛浣哥虹涓哄绐扮哥涓10杩澶锛涓哥跺哥虹哄骞冲绐版18锛澶涓涓浠22涓挎哥骞冲哄绐版209锛澶涓涓哥浜洪杈1363锛

姝ｅ父缁哄缁害浼风澶村锛撮搴涓界浜虹虹缁哄瀹风澶村锛涔辨炬ｏ界浜虹虹缁灏卞峰杩濂崇澶村锛涓蹇磋

哥虹涔浠ョ澶锛涓や釜涓昏锛绗锛句腑瓒杩50绉寮鸿寸╄川璋寮鸿寸╋灏辨借瀵煎哄绐╋姝ゅ哥绐澶涓归戒濂绗锛惧洪ㄧ浼ゅ澶э浼瀵艰寸缁锛浜轰韩藉浼淇杩风缁缁锛涓昏娉灏辨瀵煎共缁垮瑁锛ヤ骇扮ュ讥琛ュ缁缁锛挎哥灏变浜х澶村-淇-村-淇濡浠ュ帮浠讳涓娆″共缁垮瑁芥浜х绐芥э姝よ绉挎村-淇寰涔浼绉疮澶ч哄绐㈡т姣瀵艰磋涔被浼肩

涓借涓ラ鹃炬寸杩ㄤ璁浣ㄦワ充娇鹃句腑涓换浣寮鸿寸╋浠浠瀵硅虹缁㈡ф浼わ烘哥绫讳技村-淇寰锛涓瀹浼绉疮哄绐锛挎浠ュ锛淇杩虹浜х堕撮

浠负浠涔冲哄绐扮

涓虹哄绐瓒澶锛瀵硅╀骇х藉瓒寮!

缁瀵硅╃у缁瀵规绱х被浼硷芥杩轰扮斤ヨ胯╁瀹诲汇姝ｅ父缁瑕杩烘扮芥甯稿伴剧锛涓虹灏卞哄浠娣诲瑰浠讳ㄤ欢锛介瑕舵瑰寰澶涓瑗匡寰澶跺界灏卞瑕缁规6哄涓涓涓虹斤甯稿伴俱绐灏缁灏卞北瀵ㄨ规猴寰澶朵欢芥㈣锛璧锋ユ杈剧锛浣缁瀹涓哄戒涓瀹规界虹缁规氨涔变璧锋ョ朵欢锛寮甯搁剧锛浣涔甯哥垫椿锛涓斤涓涓灏寰尝芥姐

姝ｅ涓鸿虹浜90%芥哥锛浠浠缁绐澶锛浜韬查胯╋姝ょ澶у拌虹╂炬规不锛涓璁烘杩跺娌荤锛澶介甯搁

浜哥涓哥虹哄绐绉绫讳

涓ょ虹涓浠扮锛撮瑕绉绫讳涓瀵逛釜锛界堕芥板涓锛浣朵腑甯搁芥涓涓富瑕绐锛瀵圭胯捣拌冲抽瑕浣瀛浠杩绫婚瑕绐椹卞ㄧ虹锛Driver Mutation锛锛涓哄浠朵灞璧板虹涓瑕椹卞ㄧ哄3涓KRAS锛EGFRALK锛哥虹涓富瑕KRAS绐锛涓哥虹涓昏EGFRALK绐

涓哄ュ冲绐锛

涓洪瀵EGFRALK绐锛杩骞村轰澶涓甯镐板跺╂不锛KRAS绐娌℃规杩绫婚跺╁ㄧ浜鸿韩涓姣濂斤撮瑕病ｇ楠ㄩ剁涓ラ姣姝や娇ㄩ跺╃EGFRALK绐虹浜虹娲昏川瀛娲荤杩瓒KRAS绐虹浜恒村缁浼ㄥ袱

涓哥虹浜哄虹朵骞革浣瓒杩50%藉EGFRALK绐锛澶绉板跺甯╋涔杩浜浜虹绐扮杈灏锛浜хф杈缁煎杩涓ょ癸EGFRALK绐涓哥虹浜烘虹浜烘甯挎卞锛涓烘㈡х剧浜虹兢

荤锛

1. 涓轰涓寰虹锛璇蜂瑕哥锛

2. 涓轰寰浜虹姣杈濂芥不锛璇蜂瑕哥锛

锛浣锛锛╁澹

[1U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the U.S. Surgeon General, 2004.

[2]Govindan R, Ding L,et al.,Genomic landscape of non-small cell lung cancer in smokers and never-smokers.Cell. 2012 Sep 14;150(6) :1121-34