浠浣浣

娉宸茬磋捣澶骞达浣杩涓娉充浠瀛璁稿浜璁娉杩寰浜杩灞锛瀹瀹ㄥ William C. Gause灏璁╀瀵硅涓娉翠负娣卞ョ璁よ

2006骞达涓浣涓Jasper Lawrence峰ュ伴娲诧璧よㄨ浜轰娉╀腑琛璧帮濂借繁涓╄浠涓朵涓浜娉″涓凤璁や负宸ヤ绀句澶存锛浜轰滑ㄤ负繁垮浠ュ韬杩琛娑姣讹朵娑浜轰涓涓冲抽瑕ㄥ锛

杩涓娉瑕浜轰滑杩芥璁╁跺ㄧや版瀵О杩疯界瑙ｄ绯诲韩剧锛濡杩浼х娑插锛inflammatory bowel diseases 锛IBD锛浠ュ澶х‖锛multiple sclerosis 锛MS锛缇介╃灞锛The Food and Drug Administration锛杩骞舵瑰娉锛惰Lawrence浜2007骞村濮杩缃缁ㄧ扮韩ｈ哄繁瑰荤濡浠锛浠凡缁╁颁卞藉

Lawrence杩绫诲杩灞浜板翠涓锛惰绌惰浠瀵互瀹浠郴缁褰卞杩琛绌跺凡缁板骞翠缇界兼ぇ瀛Rutgers University锛涓涓讳换William C. Gause浜20涓绾80骞翠唬寮濮瀵硅韩娉杩琛绌讹骞跺2004骞村濮灏惰涓轰绌堕广杩骞搁瀵硅涓棰寰杩灞璇锋浜Gause锛浠ヤ充负浠虹澶

娉涓昏ㄤ不浼х娑插锛濡婧℃х互姘瀵逛娉ㄦ不杩浜剧涓寰锛浣藉浠涓句浜妗渚锛

涔╃凹浜宸浣浼х娑插ｈ锛绫诲洪娉瀵逛娌℃浜浜娉板斤ｅ跨荤璁╀浜浜哄伐瑰荤ヤ寰蹇氨濂借浆浜锛杩句互缃俊

瀵浠ュㄤ瀛娲诲骞达ㄥ浠寮浠ュｄｈ娆℃ｄ浜浼х娑插涔ч灞卞ぇ瀛浜娌荤锛浣骞舵病濂借浆荤浠璇浠锛濡浠版嘲藉ｄ浠浠瀵逛杩琛璺韪褰褰朵锛杩浜藉伙浣浠ヨㄤ浜跺浜濂借浆

涓浣涓Png Loke绌跺浜繁娲荤缁妫ユ版缁浠搴浜涓浜甯告瓒ｇㄨ瀹崇归瀵技涔捣瑕浣ㄣ瀵硅涓碉Loke浜2010骞村ㄣ绉瀛浆璇诲锛Science Translational Medicine 锛涓琛ㄤ涓绡稿宠ｇ釜浜哄绌躲

娉绌惰寰浜捐

绫诲1/绫诲2搴姒蹇电灞20涓绾80骞翠唬寰瑕灏便浜轰滑浠ｆ跺寮濮浜瑙ｅ板搴涓轰袱绉涓绫诲绫诲1ㄦ姣涔搴锛杩风搴浼淇浣跨瑰缁婵绱锛郴缁浼褰卞跺缁娉╋

绫诲2涓绫讳搴锛杩风搴浼ㄦ杩风搴涓辫寮搴寰澶镐技版癸浣涔涓涔澶

ｅ氨杩藉浠ュ稿搴锛涔灏辨被2搴锛浣技涔浠ュ搴锛杩浼у搴杩负浠涔

界朵杩芥浜撅涓哄浠戒寮绫诲2 搴锛浣涓逛搴娑村璋锛郴缁跺搴╄川锛ㄤ汉浠凡缁妤浜锛浼寮绫诲2 搴锛惰浼楂璋缁缇ょ伴杩涓よ缁灏变褰㈡靛尽瀵淇ゆу搴

浣借В涓涓浠涔淇ゆу搴锛

褰ㄧ缁绉诲ㄦ讹变浠绌胯缁骞跺娉锋村х剁被锛姝や瀵逛汉浣涓瀹浼ゅ涓杩浼淇浣夸浜璁╀激瑕浜х锛杩灏辫瀵寰涓ｄ璁╀汉惧

淇ゆу搴浠ュ涓轰袱绫汇涓绫讳负靛尽锛杩涓绫诲搴缁浼椹辫蛋涓绫讳负蹇锛杩绫诲搴浼璁╀汉浠辩锛舵朵甫ョ浼ゅ杩ㄨ搴涓苟涓甯歌杩搴涓被2 搴镐技锛瀹ㄤ躲杩风搴缂轰寮璋搴

娉浠ユ不璁稿剧锛姣濡澶х‖浼х娑插绯灏跨杩宠ｄ杩浜涔存ㄥ宠

锛瀹浠寸‘瀹绯汇杩浜剧戒瀵艰村郴缁虹锛骞堕涓ラх‖I绯灏跨浠ュ浼х娑插杩风剧锛涓虹虹灏辨被1搴杩风搴灏卞″遍绾垮杩浜涓剧绯诲ㄤ璧枫

濡瀹崇纭涓涓瑕归ｄ璧风绫诲2搴锛涔灏辨寮璋锛涔璁稿氨藉剁

娉″璁や负锛ㄥ勾骞兼舵瑙瀵瀵逛汉浠郴缁澶ф瑁ㄧ杩负浠涔

杩灏遍瑕冲板挎堕村ㄥ涓讳碉挎堕寸浼浣垮涓诲板杩寰界涓绉靛氨杩风杩浼冲跨浣褰㈡搴缁淇浣胯芥舵瀹崇浜х

ｄ浠板搴涓搴璇ヨ瀛╁浠ㄥ勾骞肩跺

璁や负杩涓藉姝や瀹璁恒杩杩瑕村娴璇涓杩璁や负娉娼锛璁歌界ㄦュ芥舵瀹崇韩浠ュ璋瑙寰杩搴璇ユ浠繁ョ绌剁涓涓瑕棰

灏辩ヨ锛杩绋瑰库瑰挎跺ㄨ涓娉浜轰滑瑕涔借辜瑕涔璁╄ㄧや娌℃介杩朵瑰ユ

杩涓绉规灏辨浠ㄨ杩ㄨ舵╄川濡浠藉娓┒绔浣寮璋锛ｄ灏辫藉╃ㄨ涓癸涓浣跨ㄦ椿

涔璁╀瑙寰杩涓棰绌惰骞朵

浠杩寮濮灏跺杩ㄤ复搴璇楠锛惰瑕ц骞跺杩风涓村璇楠锛瑕辫垂澶骞寸堕淬骞朵璁や负浠己涔锛娉ㄥㄧ涓涓甯哥灞舵

瀵逛瀵ㄤ汉绫讳复搴璇楠涓椋╁绠＄灞浣搴

浠浠凡瑰灏碉TSO锛浣涓虹ㄤ复搴璇楠拌杩涓烘浠ㄤ复搴璇楠涓寰杩姝ユ渚浜′欢TSO弗兼ц╃浜ц川瑙朵锛骞朵宸茬ㄤ复搴璇楠涓ㄤ澶骞淬杩璁哥ㄤ复搴璇楠绯荤棣硅╀腑涓涓甯浠ュ藉瀹浠村绌躲

瑕璁╄娉寰版瑰锛ㄦ澶х涔

涓昏堕淬瀵逛垂锛浠朵浼瀚灏锛浣涓寰涓璇存浠病寰扮垂

瀵逛娉锛浜哄ㄥ璁锛

ㄥ浜轰滑ㄨ娉讹讳瀛ㄢ跺涓杩ㄦワ剁辫绫诲2搴剧璋锛宸茶骞挎璁や负涓煎娣卞ユ绌剁瑰

瀵ㄥ澶х遍╂уㄧ嚎璐拱

瀵逛ｄㄦ揪娲昏不浜猴ㄥ剁舵规娌荤浜虹碉跺杈蹇浠苟涓虫ヤ锛涓璧浣跨ㄨ娌℃杈惧板寮姘村钩娉棣搴璇ョ‘瀹杩浜娉瀵瑰楠妯″锛跺灏惰ㄤ复搴璇楠涓涔借ㄥ扮浜舵涓村璇楠锛瀹楠缁

浣瀵硅浜凡缁琛浜寰挎堕寸绌讹ｄ濡浣ｄ浜涓杩版绉锛浣浼锛

宠娉宸茬浜寰澶浠や汉蹇ㄧ妗渚锛涓杩瀵逛璇杩绉娉浠ц瀛璐ㄧ涓鸿浠涓烘锛浠ф病娉惰蹇椤昏娉姣濡锛杩浜ワ哄甫浜浠涔缁杩浜芥‘瀹瀛ㄧ遍╁绱锛寤鸿浜轰滑蹇浜锛娉绌剁浼风灞缁芥浜锛瀵瑰涓浜涓璧蜂ㄣ瑕璁╄娉涓虹姝ｉㄤ娉锛杩瑕浠卞骞寸虫村堕村绱

浣锛Julia Calderone锛╁瀹跺虹绉瀛瀹讹灞浣╃凹浜宸锛璇锛娴峰甫涓锛瀹℃★炽