涓哄娓革浣澶濂介茶瀵ㄥ＄姣浜锛

藉锛涓灏浜洪╀哄娓搞

灏卞ㄤ涔锛920ワ藉璐ㄦ诲甯锛寰椹ヨタ浜琛娑璐硅″娉ㄦ＄姣锛ㄩ┈ヨタ浜村娴ュ悍舵锛濡琚骞跺虹圭舵讹搴褰跺氨汇

瀵ㄥ＄姣浼间婕

跺锛浠娲诲ㄥ婊＄寰╃澧涓杩浜寰╋灏ゅ舵姣锛涓缁村氨浼虹版浠娲汇

姣濡2002-2003骞村浜藉ㄧ糕锛2009骞撮浜缇插H1N1娴锛2012骞翠腑涓板烘村涓煎哥患寰锛2013骞存藉板虹H7N9锛2014骞存村浜タ锛浠ュ2014-2016骞磋腑缇床ㄧ寤剁瀵ㄥ＄姣

界舵姣村芥ュ挎惫姹癸浼兼甯峰ㄧ涔匡浣瑕浠瀛拌璇绉瀛伴㈠骞朵绉瀛板浠ラ叉わ浠讳涓绉姣戒褰琚汉绫诲涓荤达

浠澶╂浠氨ヨ杩瀵ㄥ＄姣

浠涔＄姣

瀵ㄥ＄姣卞＄姣寮璧风

1. 37典锛甸涓瀵ZIKV褰㈡锛Kostyuchenko et al. 2016锛

1剧ずㄧ甸涓瑙瀵扮瀵ㄥ＄姣锛Zika virus, ZIKV锛褰㈡锛褰村40-70 nm锛瀵ㄥ＄姣瑁圭变℃RNA哄缁锛跺ぇ灏害10.8 Kb

瀵ㄥ＄姣杩浣杩浜诧濡婚╃姣榛姣浠ュ瑗垮凹缃娌崇姣,浠浠藉浜姣绉榛姣灞

瀵ㄥ＄姣寰浜跺般

1947骞达杩榛姣妫娴缃缁锛浜轰滑剁跺ㄧ娲讳娲蹭骞茶揪瀵ㄥ′娌崇翠腑浜涓绉扮姣锛骞跺跺藉涓哄＄姣1952骞达ㄤ骞茶揪灏间浜虹兢涓妫娴颁瀵ㄥ＄姣浼澶骞存ワ杩绉姣浠ㄩ娲插浜板哄虹ｅㄦ渚锛╃涓娆℃村2007骞村ㄨタ澶钩娲瀵缃灏间缇ゅ插锛纭渚浠涓49渚惰2013骞翠互ワ瑗垮お骞虫缇床娲查缁ュ瀵ㄥ＄姣纭渚锛颁2015骞达ㄤ腑缇床杩╂ｏ朵腑宸磋タ涓洪惧恒锛澧涓浜浜娲茬锛璇ョ姣宸叉尝ㄧ70涓藉板猴戒ラ浜颁杈ュ渚

涓轰涔浠病蹇瑕瀵ㄥ＄姣锛

界跺＄姣浼搴锛娉㈠村箍锛浣浠病蹇瑕瀵硅涓姣

锛娌℃璇〃＄姣浼ㄤ汉涓汉涔翠涓浼涓烘瑙ｈ

瀵ㄥ＄姣涓昏杩濯锛浼锛浼浼瀵ㄥ＄姣锛杩娆″姣浼朵浜恒涓扮瀵ㄥ＄姣浣杩浜蹭杩濯浼浼寰澶绉绫伙瀵ㄥ＄姣涓昏杩浼浼2锛

2.瀵ㄥ＄姣浼瑰浼锛diyitui.com锛锛ф瑙hljtv.com锛锛琛娑蹭xmxz.org.cn锛姣濠翠sccnn.com锛

浼ㄥㄧ甫板哄箍娉甯锛界娴峰骞夸峰宀浜杈瑰哄婀惧ㄩ芥跺甯や浼浼瀵ㄥ＄姣涔缁跺瑰浣芥杈灏瑙锛濡杩ф瑙琛娑蹭涔炬ラ璇瀹瀵ㄥ＄姣浠ラ杩浼濠村匡2锛界朵钩姹涓藉妫娴板＄姣RNA锛浣灏娌℃杩轰钩扮跨ラ

界朵汉缇ゅ瀵ㄥ＄姣锛浣80%浜烘ф锛充浜х讹20%浜轰涓村讹琛ㄧ涓哄广宠缁锛涓缁7澶╋涓瑕虹瑰锛浠ュ娌荤涓轰富灏版ｈ藉虹兼-宸存患寰绛绁缁韩у苟锛浣杈涓虹瑙

浣瀛濡瀵ㄥ＄姣戒寮璧疯垮灏ご稿舰2015骞翠骞达宸磋タ村瀵ㄥ＄姣浠ユワ扮垮ご稿舰澧夸杩20锛涓灏瀹楠涔琛ㄦ＄姣瀵艰磋ㄢ绁缁澶ч浜★澶с锛琛ㄧ涓哄稿灏ご稿舰锛3锛

3. 扮垮ご稿舰绀烘撅cdc.gov锛

灏界濡姝わ灏璇〃濡姣朵浜虹兢瀵硅姣存涓锛ㄥ＄姣板猴澶у板濂充跺浠ユ甯稿濞┿姝わ澶瀛瀛涓濡濂虫锛涓灏ご稿舰浠ュㄥ濞杩B瓒杩琛绛ワ浠ワ寤鸿剧寰娲诲ㄥ＄姣虹瀛濡杩琛甯歌浜у妫ュ苟诲′汉ㄨ锛у荤寤鸿寮鸿挎娴

灏界杩娌℃瑰涓甯浜у锛浣凡缁涓绉板瀵ㄥ＄藉淇ゅ娌崇村瀵ㄥ＄姣锛涓娌℃涓搴锛涓ょ宸茬杩ヤ涓村璇楠ㄦ不╂归绌朵汉涔浠6000绉╀腑涓绫绘不瀵ㄥ＄娼ㄨ╋寰杩涓姝ョㄧ╁楠浠ュ涓村璇浼般ㄤ腑浣归澶汉婧浣琛ㄧ哄瀵ㄥ＄姣楂涓娲绘э涓浣浠ユ淇ゅ垫瀵ㄥ＄姣

变病瑰娌荤╀甯锛棰叉惧涓洪瑕锛朵涓锛浼娆㈠ㄦ娲灏Н姘翠腑浜у垫锛瀹瀵瑰瀹ゅ婊拌琛娓浠ヤ澶翠娑姣杞戒浼搁浜鸿锛涓ㄧ藉ぉ汉锛榛榛负娲诲ㄩ宄帮浠ュ灏介胯。胯￥锛垮ㄨ浜舵ㄥ澶缁垮扮浼杈澶版瑰瀹跺涵浣跨ㄨ甯瀹瑁绾辩棣绛娈甸茶锛浠浼寰锛4锛

4. 茶琛chinanews.com,chancheng.gov.cn,21cn.com锛qq.com锛

姝ゅ锛变璇〃＄姣杩х辨瑰辩锋т缁濂虫э涔卞コт缁锋э瀵ㄥ＄姣ｈㄤ姣娓や锛搴绂姝㈡х娲伙ㄦх娲绘朵娇ㄥㄥ锛叉浼浠浜恒

:

[1]Barbaspaeth G, Dejnirattisai W, Rouvinski A, et al. Structural basis of potent Zikadengue virus antibody cross-neutralization[J]. Nature, 2016.

[2]Kostyuchenko V A, Lim E X Y, Zhang S, et al. Structure of the thermally stable Zika virus[J]. Nature, 2016, 533:p谩gs. 425-428.

[3]Musso D, Roche C, Robin E, et al. Potential sexual transmission of Zika virus.[J]. Emerging Infectious Diseases, 2015, 21(2):359-61.

[4]Miner J J, Cao B, Govero J, et al. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.[J]. Cell, 2016, 165(5):1081-1091.

[5]Stettler K, Beltramello M, Espinosa D A, et al. Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection.[J]. Science, 2016, 353.

[6]Xu M, Lee E M, Wen Z, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.[J]. Nature medicine, 2016.

缃绔:

涓缁缁缃绔锛http://www.who.int/en/

涓界炬涓缃绔锛http://www.chinacdc.cn/

缇界炬涓缃绔锛http://www.cdc.gov/

哄锛绉腑

朵锛涓界瀛㈠井╃绌舵 濂у绌跺

讹涓界瀛㈣绠虹缁淇℃腑蹇

绉腑解腑界哄绀句瑰╃ㄤ俊娈靛灞绉瀛绉瀛濞

辩腑借浣哄锛杞浇璇锋敞哄