【摘要】褰版堕2016骞85ワ绗31灞澶濂ユ瑰杩ㄤㄥ反瑗块绾㈡寮浜搴ヨ206涓藉板虹10000澶杩ㄥㄦ涓ョ16澶╀腑锛瀵812灞寮瑙...
惧勾ワ濂ヨ浼涓浠涓鸿ㄧ簿绁璞″锛杩浜х浜宸ㄥぇ搴浠ワ灏界浜轰滑绾风悍妲解杩灞濂ヨ浼涓璋憋濡璀缃㈠伐藉伐寤舵姘磋川涓杈炬绛锛冲轰瀹ㄧ涓锛姣璧绗锛浠瀵瑰跺婊′寰
涓杩锛煎蹇цㄨ轰澶锛浜轰滑杩ㄧ浼间ㄥ涓椤硅ユ剧ず锛浠2008骞村2012骞达绡妫瓒崇杩ㄧ榫瀛╁锛6~17宀锛浜惧涔濡浣瑙寰杩绉澶у锛d锛寸杩ㄥご稿宠烘缁璁★杩1/4瀹堕垮凡缁ㄨ涓璁╄繁瀛╁浣茶ㄣ[1]ㄥd藉ㄧ杩ㄢ涔灏辨涔杩ㄢ涓戒瀹ㄣ变ㄤ腑涓浼わ韬戒辨浜х㈡у浼ゆц锛杩绉椋╂汉涓挎垮
ㄧ颁
㈡у浼ゆц锛Chronic Traumatic Encephalopathy锛绠绉CTE锛锛椤惧涔锛瀹棣绉ㄧ剧锛舵卞浼ゅ璧风锛杩绉浼よ㈡х锛$绐舵т浠躲
浠氨ヨ璇磋ㄣ骞冲璁猴浜轰姣釜ㄥ藉瑕ゅ浠ユ垫$传澶绾匡榻胯藉纾ㄧ┿充娇灏捐风澶浣ㄥ锛涔涓寤鸿棰叉уゃ涓杩锛涓ㄥ颁骞朵骞崇锛ㄥ浜濂藉涓瀛锛璁虹锛ㄦ澶锛璁哄斤ㄦ瑕锛璁虹绌跺锛存绁缁绉村扮惧勾[2]杩灏变娇寰充ㄩ绉瀛绱㈠甯告叉锛寰澶涔浠ヤ负甯哥缁璁猴藉ㄤ涓灏辫扮绌剁缈讳姣濡姝讳骸哄讹涓村涓姝讳骸姝讳骸浠ュ璁や负锛朵ㄥ琛扮杩绱锛瀵艰磋缂烘哀缂鸿锛涓ц姝㈠伐浣锛扮绌跺存剧ず锛瀹芥版扮稿ㄤ富ㄧ朵ㄥ涓杈句姝讳骸浠わ寮瀵间汉浣瀹姝讳骸杩绋[3]
浜虹ㄧ辨板浜夸釜绁缁缁锛璋浜轰裤层琛拌锛宸浜轰缁淬杩剁蹇寮虹剁缉ㄣ灏界浣瑙涓拌绉讹浣瀹灏卞ㄩi锛涓绂讳寮杩浜澶藉椤昏濡ュ缁淇わ杩浜缁浠ュ涓哄澶涓らㄥ
浼ょ卞
ㄧ澶ㄤゅ浠ュ涓轰灞锛棰楠ㄥ杞缁棰楠ㄥ纭朵腑锛棰楠ㄥ杞缁甯歌澶寸辫涓剧缂缁缁绛锛瀵规绘涓瀹缂蹭棰楠ㄦ澶浼ゅ剁涓昏ㄤ锛浠ュ㈡涓瀹фэ猴[4]纭灏瀹村板瑁硅捣ワ涓归㈡垮e棰楠ㄦ藉锛涓归㈠璧峰版浣ㄣㄥTau姐
垮寰㈢姘存偿憋妗跺涓ワ璧杞冲猴蹇椤婚ㄥ锛朵叉躲绁缁涔涓渚澶锛缁楠ㄦ跺氨缁姘存偿便叉躲绁缁缁楠ㄦ朵富瑕卞井绠$锛Tau戒涓哄井绠$稿宠斤microtubule-associated proteins锛MAPs锛涔涓锛浠ョㄥ井绠$琛ㄩ㈡浣垮井绠¤搴锛瑙h搴锛浠璧峰拌寰缁瑁骞剁淮剁ǔ瀹х浣ㄣ[5]
涓杩锛姝f璋浜哄惰绌封灏界ㄧ淇ゅО杩濂杩逛涓锛褰轰扮浼よ烘涓讹瀹涔戒负浼ゆ浼ょ涓绉锛舵哄朵富瑕涓ょ锛涓绉浣ㄤご浣块楠ㄥ锋楠ㄦ锛杩绱拌缁缁锛涓绉稿锛澶撮ㄥㄩ澶涓楠ㄥ稿杩棰楠ㄧ涓涓姝e父锛藉寸变х★虹纰
瀵逛绉锛浠浠ヤ妇涓瀛ヨㄨ杈杩绋涓浠涔甸芥藉涓涓ュ硅溅锛杞涓浜锛楦¤寸变э缁х画淇杩濡姝やワ灏变汇蹇澶瑁芥濂界锛楦¤村凡缁翠浠ワ缁父缃璐界ラ寮绠辨ョ瑕с
㈡у浼ゆц涓浜
㈡у浼ゆц绌舵浜涓涓瀵澶瑙版ュㄧ杩绋讳瀵艰磋浼わ杩涓规‘瀹浣杩绉浼ゆ杩х芥х锛杩夸х锛藉寸瑰锛虹惰垮楂搴伙渚濡澶寸杩绉稿ヨ锛搴杈浣伙浼涓浼绱Н浣ㄥ寸杩浜锛璇浜澶ч绌躲20涓绾20骞翠唬锛冲绘璧杩ュ濂ヨ浼椋″ㄧ锛浜轰滑寮濮娉ㄦ帮冲绘杈瀹规d胯叉捣榛绛ㄧ剧褰讹浜轰滑璁や负锛杩借冲绘缁父拌ㄦ绘筹骞跺剁О涓烘冲绘村[6]1928骞达版辰瑗跨涓浣诲ㄤ功涓ㄢpunch drunk锛琚寰澶磋浆锛堪冲绘寮甯革涓轰浠浠澶卞浜绉诲ㄥ钩琛★涓ㄦ缁翠涔姣甯镐汉褰㈠[7]
绌剁涓繁ヤ互绌舵娈电涓锛瀛浠锛″苟涓绉涓杩х介纰锛ㄥㄩ″虹缁瑰锛濡绁缁绾跨浣杞寸胯锛娑蹭腑涔拌纰便剧瀛楂绛颁1984骞达缇借ㄥ诲绌惰杩ㄥ轰甯稿浣搴楂棰娆$$О涓鸿ㄧ稿虫ц★SportsRelated Cerebral Concussion锛 SRCC锛锛浠ュ哄父瑙涓(Cerebral Concussion锛CC)涔涓锛浼间濡涓ラ锛姣濡甯镐浼虹涓уけ绛讹涓杩锛浠胯锛瀹浼瀵艰翠弗绁缁浼わ寮璧峰涔璁板归㈢纰[8]
瀵逛裤冲绘璧骞涓讳滑ヨ锛杩风绌惰舵璁ㄥ姣璧剁纰版ㄦ惧锛规藉姗姒锛National Football League锛NFL锛瀹圭璁℃板锛姣NFL骞冲姣釜璧瀛hㄨ轰瓒杩1500娆¢瀵瑰ごㄧ汇[9]濡杩浜浼瀵艰翠弗锛d锛姣涓渚芥澶х辨澶便
㈡у浼ゆц锛CTE锛
褰讹涓浜锛涔借戒躲浜澹寰锋捐锛剧卞惧锛炬寸辩瀹涓浠ヤ缂轰浜猴绉灞缁浜浠浠绌剁′欢锛姘磋界冲哄堕撮2002骞9锛杞瑰版ヤ锛ㄨ娈垫堕村锛璐灏肩孤峰ゥ椹荤瀵逛濂缇冻杩ㄥ杩路集硅琛浜灏镐瑙e涓涓瑙涓濡姝ゆ甯哥澶ц锛涓轰涔浼澶寸澶卞绛讹缁浜х蹇靛ご瀵逛风璐灏肩孤峰ゥ椹荤娌℃姝㈡浜父瑙妫ラ」浠冲寮绠遍璐р锛瀵硅ㄨ琛妫ワ缁骞跺藉浜㈡у浼ゆц
璁や负锛㈡у浼ゆц绉卞澶诲璧风绁缁琛х锛涓璺婚寮哄害瀵稿炽涓村涓虹瀛璁板杩ㄧ藉锛琛ㄧ烘激惧绛琛涓虹瑰CTEhㄥㄥ瑙涓寮甯革涔虹棰缉瀹ゆ╁绛琛ㄧ[10]ㄥCTE稿瑰锛Tau藉甯歌[11]
浠ㄥ涓帮Tau藉浠ヨ寰锛瀵逛淮绁缁缁瑕浣ㄣ跺锛や缁涓璐$澶锛Tau锋瑕姐涓归Tau浠ヨ绁缁╄川杩杈锛宠酱娴杩杈绌跺锛Tau芥部绁缁杞寸姊害甯锛ㄧ瑙楂锛╀杩杞存杩杈涓归Tau藉浠ヨ缁淇″璺崇存涓缁芥㈠姣濡ㄧ缁缁烘讹Tau藉浠ヤ缁DNA缁锛淇杩DNA淇
姝e涓Tau锋濡姝ら瑕浣d锛Tau寮甯歌杩搴7稿卞灏辨煎涓ラ灏ゅ舵扮绌惰〃Tau藉浠ョ┛杩绐瑙颁缁娴烽┈猴骞惰涓姝ヤ颁捣椹绯荤恒涓澶虹寮甯革介娓╂o瀵艰村ㄨ寮甯搞[12]
规Tau界绱ㄤ绋搴CTE浠ュ涓哄锛涓浠ュご涓哄稿瑰锛杩藉虹娉ㄦ锛浜h虹璁板涓уけ锛骞朵即磋缁涓锛璁ょラ纰宸茬撅绀轰ц浼わ剧涓ラ舵锛涔舵锛h藉虹村璇藉锛宠姝讳骸璞°
㈡у浼ゆц锛CTE锛绂绘浜烘澶杩锛
浠ヨ灏肩孤峰ゥ椹荤涓哄靛奖℃搴ㄥ澶ч㈢嚎哄CTE娓琚ぇ浼ャ瀵逛箍澶ц瑷锛冲CTE绌剁绂绘浠澶杩剧涓澶х瀹舵朵腑姣涓戒濂芥癸寰寰瑕颁唬虫板浠d汉诲锛CTE浣涓哄朵腑板虹涓锛界跺拌ヨ澶虫敞锛稿崇绌朵涓繁ワ浣浠舵璋
棣锛杩浠涓烘ラCTE渚ヨㄥㄥ案妫浠ュ父璁猴褰杩ㄥ虹涓ラ藉甯哥典锛浠浠浠浠瀹朵汉浼哄案浣锛ㄤ诲绌躲杩风逛藉唬琛ㄥㄩㄨㄥ锛灏ャ舵锛CTEㄧ涓村琛ㄧ涓锛涓垮规捣榛璁稿镐技涔澶绌剁CTE绉扮剧锛杩垮规捣榛绉锛娌℃涓涓濞璁╀汉淇℃绌躲[13]杩ㄥ轰婚甯稿凤涓浠涓杩ㄥ圭癸蜂版姣璧姣釜杩ㄥ锛芥璁稿涓濡浣杩浜伙缁CTE涓涓‘璇锛
?瀛瀵规浜璁澶锛扮己涔荤肩跨杩姣虹浼ょ跨澶锛涓浜瀛璁や负澶稿ぇ杩ㄩ瀹虫虹[14]绗璧杩涓瑙癸澶撮ㄦ浼ょ遍╂у涓ラ绋搴充堕″己搴跨灏涓舵蹇цㄥ介浼わ涓濡蹇ヨ绛寮璧风楹荤褰讹ㄨㄦ讹瀹堕裤甯缁涓瀹瑕娉ㄦ瀛规寮哄害锛姣濡瑕插跨浠ユ纭濮垮垮瀵瑰ご锛瀛╃ㄩ楠ㄨЕ锛╃ㄩㄨ跺ごㄥㄤ锛跺╃ㄨ韩浣韬共涓ごㄣ棰ㄧ杩浠ユ澧澶撮ㄥ诲诲锛浠澶撮ㄧ搴[15]讹瑕璀浠讳杩ㄥ虹澶寸讹蹇瑕跺璇ュ婚㈣琛妫ャ
1锛Steven,R.(2015,December 22).Parents,Stop Obsessing Over Concussions.The New York Time.Retrieved July 1,2015,from www.nytimes.com
2, 蹇璇. 绁缁绉[J]. 绗 l . 浜: 绉瀛虹绀, 2000锛1
3, Tanya,Lewis&Staff,Writer.(2015,April 6).Near-Death Experiences: What Happens in the Brain Before Dying.livescience.Retrieved July 1,2015,from www.livescience.com
4, 宸, 璧靛缓. 浜哄伐棰楠ㄤ汉浣棰楠ㄧ烘瀛ц[J]. 绌跺, 1991, 5(5): 455-459.
5, 璧靛, ㄥ. Tau 借搴7稿寸哄跺跺ㄥ浼ゆц浼や腑浣[J]. 绉瀛灞, 2014, 45(3): 213-216.
6, McKee A C, Cantu R C, Nowinski C J, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury[J]. Journal of Neuropathology & Experimental Neurology, 2009, 68(7): 709-735.[J].
7, Omalu B I, Bailes J, Hammers J L, et al. Chronic traumatic encephalopathy, suicides and parasuicides in professional American athletes: the role of the forensic pathologist[J]. The American journal of forensic medicine and pathology, 2010, 31(2): 130-132.
8, 绁, 浜缓浜, 璁稿拌, 绛. 杩ㄧ稿虫ц$绌剁[J]. 涓借ㄥ诲蹇, 2006, 25(4): 502-504.
9, 辨.锛2011 August12锛.㈡у浼ゆц锛璧虹‖姹澶村. 涓娲诲ㄥ.Retrieved July 1,2015,from www.lifeweek.com
10, Stern R A, Riley D O, Daneshvar D H, et al. Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy[J]. Pm&r, 2011, 3(10): S460-S467.
11, Baugh C M, Stamm J M, Riley D O, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma[J]. Brain imaging and behavior, 2012, 6(2): 244-254.
12, McKee A C, Stein T D, Nowinski C J, et al. The spectrum of disease in chronic traumatic encephalopathy[J]. Brain, 2013, 136(1): 43-64.
13锛Karantzoulis S, Randolph C. Modern chronic traumatic encephalopathy in retired athletes: what is the evidence?[J]. Neuropsychology review, 2013, 23(4): 350-360.
14, Fitzgerald S. Is There Too Much ObsessingWith Concussion? One Neurologists Says Yes in New York Times Op-Ed; Not Everyone Agrees[J]. Neurology Today, 2016, 16(3): 10-11.
15, . 澶寸浼?[J]. 瓒崇璁轰璺, 2005 (1): 13-16.
特别声明
本文为 绾胯氨 原创发布,仅代表作者观点,不代表冬镜品知网的观点或立场,冬镜品知网仅提供信息发布平台,合作供稿、侵权删除、反馈建议请联系 520@520xx.cc