扮绌朵负寮姣╂瑰

浠2013骞村濮瑗块姣锛涔浠涓ラ鸿锛遍杩3涓浜烘ｇ锛瓒杩1涓浜烘浜★缁颁汉涓浜舵璁板界剁宸茬钩浣变姣鸿浜＄楂锛涓充浠舵病娌荤斤姝や峰ワ浠舵介鹃炬х姝わ界绌朵汉戒㈡锛浜澶虹寮娌荤鸿┿涓椤规扮绌舵涓虹稿宠╃绌朵汉扮瑰

姝ゅ宸茬璁＄烘ā浣澶瀹楠ㄧ╁楠琛ㄦ涓浜宸茬瑰ㄤ不朵剧╁姣涓瀹朵浣杩浜╃浣ㄦ虹杩涓娓妤ヨ卞界绌朵汉杩瀹楠琛ㄦ甯歌姝㈢娲涓绉╂绫宠(Toremifene)藉涓姣绯界哥骞堕浣剁ǔ瀹с绌朵汉杩X灏绾胯灏娴瀹浜姣绯藉ㄤ涓ょ╀ㄥ缁锛纭浜╀藉镐浣ㄧㄤ褰姣璇炬瀹夸富缁讹瀹棣瑕ㄧ藉繁搁板涓荤涓锛姝よ澶绌朵汉藉姣绯戒涓鸿╁瑕剁广

杩椤圭绌朵护浜烘锛涓鸿╃浜哄浠ユ规浜缁淇℃瀵规у板娌荤鸿╋瑰凡缁瑰涓甯╋濡藉姣朵涓村璇楠堕磋捐拌涓鸿浜╃瀹ㄦу凡缁璇瀹锛娆￠杩涓村璇楠楠璇浣涓浜哄＋涔锛瑕崇姝ｅ烘╂杩涓烘跺╋瑰绌朵腑扮甯娲绫宠涓ょ╋ㄤ复搴璇楠涓藉璧峰版不鸿浣ㄣ

references :

http://cen.acs.org/articles/94/i27/Structure-Ebola-viruss-glycoprotein-reveals.html

璁烘锛Toremifene interacts with and destabilizes the Ebola virus glycoprotein

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18615.html

炬锛http://www.ikexue.org/archives/40493