浼浼浼缁锛т灏斤ラ瑰

浼缁锛т灏斤ラ瑰

ヨ舵ㄥ锛ㄧЩ妞甯ヨ跨ょ渚锛涔舵

骞达American Journal of Transplantation蹇ラ浜涓涓舵ц跨よ浆绉绘╂ｇ缃瑙渚[1]锛琚瀹舵伴诲浣杞浇ラ杩锛1ヨ缁锛

1. 瀹舵ラ锛剧ヨ缁锛

ㄨ涓骞哥渚瀛锛涓浣姝讳鸿53宀濂虫ф繁ㄥ锛绉绘缁浜浜恒や蹇Щ妞浜烘涔虫浜触琛锛浜哄捐Щ妞浜哄ㄦ『╁版椿浜涓ャ

惰锛浠や汉杩浜洪戒骞稿板ㄥㄥ绉绘涔16涓6骞存达璇轰舵ц跨ゃ涓锛哄娴搴缁剧ず锛杩涓汉跨ら芥ヨㄥ涔宠虹杞Щ

锛灏界ｅㄥㄧ骞朵ラ繁ｆ涔宠虹锛涓缁浣妫瀹楠瀹ゆ娴X浠ュ瓒澹版尝绛涓绯诲妫ラ芥病锛濂瑰涓宸茬ｆ寰╂涔宠虹锛涓灏卞ㄨ涓浣堕借娉琚瑙妫娴扮跨ゅ╂舵锛濂圭涔宠虹缁灏卞凡缁娑叉╂ｅ颁汉恒剧ㄥ涓涔ㄥ琚Щ妞颁汉韬

涓典锛浼锛充娇涓涓汉缁介杩濂濂寰椤哄╁版ュ板澶涓涓汉韬锛涔浼琚板郴缁璇负寮宸辫娓ゆ

浣ㄨ涓渚锛浜ㄥ绉绘浜洪瑕缁ㄥ跺ユ舵寮搴锛涔灏卞寮变浠浠郴缁锛杩浣垮ヨ缁轰辨郴缁锛瀛娲讳ワ浠ヨ充涓舵俱

杩骞朵涓渚缁杩ㄥ绉绘杞Щ版浣寮璧疯跨や╁1965骞达灏卞凡缁浜跨ら杩ㄥ绉绘杞Щ缁ㄥ渚ラ[2, 3]锛姝わ荤ㄨ琛ㄥ绉绘跺锛浼垮浣跨ㄦヨ虹跨ゆ╂ｇｈㄥ

ヨ舵ㄥ锛ㄧЩ妞甯ヨ跨ょ渚锛涔舵[4]杩浜涓骞哥浜浠讹璁╃瀛浠ゆ哄充娇ㄢ舵浜轰锛涔戒浼缁锛dormant cancer cells锛瀛ㄣ

浠涔缁

充舵ц跨ょ╂ｄ浆绉伙涓涓猴╂ｇ缁ㄧ寮浜娓╁涓濮朵互涓浣浜绂讳埂棰娌娴绂伙杩浼郴缁磋拷垫姝ゅぇㄥ╂ｇ缁解ラㄦ╂ｇ涓锛灏板垢瀛缁寰浠ユ浼ャ″ㄧ浜轰涓锛挎澶浜姝㈢浼舵锛dormancy锛锛浼琚浜哄瑙锛涔娌℃琚妫娴规妫娴[5-7]

涓句釜渚瀛2018骞村Science 蹇涓锛灏辨涓椤归瀵逛缁绌[8]ㄦ杞Щ剁拌哄绠＄ｈ缁缁锋锛绌朵汉妫娴颁灏╂ｇ缁锛2锛浠浠ㄨ拌哄绠＄灏妯″锛涔峰板ㄥュ悍ㄥ浜灏缁

杩浜褰㈠褰卞缁锛瑁涔涓涔辫锛瀛ら堕跺板ㄩｉ锛澶浜舵锛灏辨缁浜

2.惧乏涓鸿拌哄绠＄浣讹惧涓哄涓浣ｈュ悍缁缁锋绾㈣蹭负缁锛ユ锛[8]锛

ㄨ椤圭绌朵腑锛绉瀛浠锛ㄥ涓╂ｇ拌哄绠＄缁锛澶чㄥ戒琚郴缁烘ユ锛寰灏扮缁锛浼ㄤ绉藉搴锛unfolded protein response锛UPR锛妯″浠杩ヤ娲昏浼舵锛朵繁琛ㄩ浜瑰瀛琛ㄨ揪锛垮涓浜锛灏辫介杩娉缃锛ㄦ涓浼捣ャ绛版涓澶╋绉瀛浠烘朵灏缁杩绉淇浼藉搴锛骞跺寮卞郴缁跺锛杩浜韬茶浜涓娉㈠郴缁澶ф娲浼缁灏卞芥轰杩ワ搴ユ椿璺挎锛3锛

3.浼缁卞郴缁娓匡ユ锛[8]锛

骞歌骞朵浼缁借藉灏扮浼缁锛ㄧ婕跨堕村虹宸у涔涓浼澶灏卞ｇ绉瀛惧颁澹ゅ姘ｆ凤т灏斤ラ瑰锛娓挎借版妫娴扮杞Щ讹浠涓浜浠跺灞哄澶х楹荤

浼缁藉や缁韩涓т互澶锛瀹ㄥ寸澧绱涔璧峰颁瑕浣ㄣ

姣濡璇达2016骞达Mikala Egeblad棰瀵肩绌跺㈤Science Translational Medicine涓琛ㄨ[9]锛堪浜浠浠ㄤ钩虹灏妯″杩娲讳惧井瀵扮涓涓璞★ㄤ浜杞Щ板洪ㄧ涔宠虹缁ㄥ达涓绉涓х缁ㄥ寰娓歌★骞朵惧轰绉涓х缁澶烽憋Neutrophil Extracellular Traps, NETs锛规缁锛ㄥ4ヨ[9]锛朵腑绾㈣茬浜洪ㄧ涔宠虹缁锛缁胯茬涓х缁锛茬涓х缁澶烽憋ㄨ浆绉绘т钩虹浜烘峰涓涔浜风缁

4.涓х缁澶烽NET锛ㄧ甸涓锛灏辨5绾㈢澶存虹ｄ缃剁锛[10]

5涓瑙缁挎锛舵涓х缁锛杩浜缁ㄤ宸ヤ跺涔璧锋ュ锛骞朵寮褰瀹浠婵娲讳浠ュ灏变惧虹剁NETNET涓х缁姝ㄥ宸ュ凤斤涔浼缁澶鸿川杩琛涓浜搴锛瑙ｄ浜斤浠涓哄娲诲ㄨ炬虹┖淬

涓х缁惧NET锛杩甯哥缁涓搴瑕缁ㄥMikala Egeblad㈤锛ㄧ瑰′欢涓锛NET涔戒璧峰颁杩跨よ浆绉荤浣褰浠浠ㄥNET锛灏辫藉灏洪ㄧ涔宠虹杞Щ[9]

杩负浠涔2018骞翠锛Egeblad㈤Science蹇涓杩颁浠浠[11]锛ワ褰洪ㄥ搴跺锛浼婵娲诲涓х缁锛璁╁浠惧NETュ灞椿ㄣ杩琛娓宸ヤ锛杩浜NETㄦц界跺锛浼跺戒绫荤缁澶鸿川杩琛搴濡杩浜搴板ソㄤ缁杩锛灏变瑰浼缁杩鸿川锛浠瑙涓绯诲搴炬ュら澶ｄㄤ涓缁锛琚娲荤缁灏辨浜缁ц灞杞Щ跨ょ姐

绠瑷涔锛洪ㄤ涓х缁灏卞垮烘NET娓缁锛灏辨芥杩浼缁缁鹃浜锛ョ缁灏卞藉灞跨ゃ

ｏ濂界绔锛洪ㄥ涓轰涔浼搴芥涓虹锛涔芥涓哄哥杩涓ら」澶у涔宠虹绌堕藉浜哥涓钩虹澶姝讳骸捐宠[12, 13]锛Egeblad㈤涔宠虹灏妯″涓插ㄩт骇句腑灏锛琚惧洪ㄧ锛藉ら╂ｅ拌洪ㄧ浼涔宠虹缁锛垮虹涔宠虹杞Щ舵涓哥灏瑕澶寰澶[11]锛6ヨ[11]锛

哥瀹冲ュ悍锛

版 | 锛绉瀛コ骞达浣诲㈣甯锛

1.Matser,Y.A.H.etal.Transmissionofbreastcancerbyasinglemultiorgandonorto4transplantrecipients.Americanjournaloftransplantation:officialjournaloftheAmericanSocietyofTransplantationandtheAmericanSocietyofTransplantSurgeons18,1810-1814,doi:10.1111/ajt.14766(2018).

2.McIntosh, D. A. et al. HOMOTRANSPLANTATION OF A CADAVER NEOPLASM AND A RENAL HOMOGRAFT. Jama 192, 1171-1173 (1965).

3.Martin, D. C., Rubini, M. & Rosen, V. J. CADAVERIC RENAL HOMOTRANSPLANTATION WITH INADVERTENT TRANSPLANTATION OF CARCINOMA. Jama 192, 752-754 (1965).

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6.Demicheli,R.,Abbattista,A.,Miceli,R.,Valagussa,P.&Bonadonna,G.Timedistributionoftherecurrenceriskforbreastcancerpatientsundergoingmastectomy:furthersupportabouttheconceptoftumordormancy.BreastCancerResTreat41,177-185(1996).

7.Demicheli,R.,Retsky,M.W.,Hrushesky,W.J.&Baum,M.Tumordormancyandsurgery-driveninterruptionofdormancyinbreastcancer:learningfromfailures.Natureclinicalpractice.Oncology4,699-710,doi:10.1038/ncponc0999(2007).

8.Pommier,A.etal.Unresolvedendoplasmicreticulumstressengendersimmune-resistant,latentpancreaticcancermetastases.Science360,doi:10.1126/science.aao4908(2018).

9.Park,J.etal.Cancercellsinducemetastasis-supportingneutrophilextracellularDNAtraps.Sciencetranslationalmedicine8,361ra138,doi:10.1126/scitranslmed.aag1711(2016).

10.Zhao,M.L.,Chi,H.&Sun,L.NeutrophilExtracellularTrapsofCynoglossussemilaevis:ProductionCharacteristicsandAntibacterialEffect.Frontiersinimmunology8,290,doi:10.3389/fimmu.2017.00290(2017).

11.Albrengues,J.etal.Neutrophilextracellulartrapsproducedduringinflammationawakendormantcancercellsinmice.Science361,doi:10.1126/science.aao4227(2018).

12.Pierce,J.P.etal.LifetimecigarettesmokingandbreastcancerprognosisintheAfterBreastCancerPoolingProject.JNatlCancerInst106,djt359,doi:10.1093/jnci/djt359(2014).

13.Wu,A.H.etal.TheCaliforniaBreastCancerSurvivorshipConsortium(CBCSC):prognosticfactorsassociatedwithracial/ethnicdifferencesinbreastcancersurvival.Cancercauses&control:CCC24,1821-1836,doi:10.1007/s10552-013-0260-7(2013).

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杩淬锛村濂界介╃瀛灏涓╁瀹堕瀹琚浠绘荤锛涓浣瀛缁缂濮浼涓璧凤涓卞姹绱浜娆¤浆杞芥浣璇疯绯fanpu2019@outlook.com