浠ワ杩浜寸椋╄灏锛

跺堕锛歌娉¤棣绛浜纭哥锛缁汉浣告惰藉杞涓鸿寸╀纭歌猴瀵艰撮圭奔绛浜х寮鸿寸╄苟锛濂虫у澧30-50%涔宠虹ｇ

хら锛澶ぉ浠ㄦ峰ら锛хわ璋蹇汉惰锛ㄧхゅ朵杩绋涓浜х涓ょ被寸╋涓绉涓烘猴绫诲楦¤楸艰锛ㄧ╁缁氨浜х锛涓绉涓轰扮苟锛ㄤ绉疮颁瀹璇卞虹

娌圭搁锛歌椋╋浼浜х澶崇锛炬楂缁韬寸藉寰澶璐╀负浣跨ㄥ娆￠澶浣跨ㄧ楂娓╂补锛濡告补★歌绛锛藉澧寸椋┿╄川锛榛查姣绱璇卞涔涓锛椋涓ヨ杩1mg/kg灏辨ф锛朵富瑕ユ娼辩锛绫崇姝ゅ锛瀹杩绠＄缃绁搁锛浠ラ绮涓涓藉楂╋娴琛瀛瀹楠绌跺锛版娣绛ぇケ革挎杩澶ヨ浜椋╋楂瀛婵绱浣虫т钩虹寸椋┿

╄川锛榛查姣绱璇卞涔涓锛椋涓ヨ杩1mg/kg灏辨ф锛朵富瑕ユ娼辩锛绫崇姝ゅ锛瀹杩绠＄缃绁搁锛浠ラ绮涓涓藉[7]

楂锛娴琛瀛瀹楠绌跺锛版娣绛ぇケ革挎杩澶ヨ浜椋╋楂瀛婵绱浣虫т钩虹寸椋[8, 9]

锛ㄥㄧ锛虹锋х存棣浣锛璇13%锛哥虹缃绁搁[10]

涓绉寸╋濡灏煎涓补涓姘у纰炽虹[11]锛瀹浠稿ヤ汉浣浜х澶ч卞猴杩搴浜轰姘у╄川姘у剁被锛涓汉浣娲诲ㄩ姘ч澶у浼虹渚姘т瓒筹挎濡姝や究瀵艰存绠′DNA瀹[12]锛浜哄婵娲伙哄绐澶辨椿锛缁寮璧风[13]

澶锛绌舵ラ锛灏煎涓ㄥ涓纭稿搴浼浜х涓绉规浜纭猴ㄥ绌烘瀹跺枫姣ょ澶杈挎堕翠句互娓わ浠澧瀹跺涵哥浜虹兢存镐椋[14]

浜寸椋╁氨涓瀹浼寰

杩浠ヤ杩版浠锛寰澶寸椋╅芥涓板娴浼涓ョ涔淇ч╂箍澶ф浼甯稿辩椋┿

ｄ锛涓鸿浜涓瑗夸澧寸锛浠氨涓逛涔锛

椋╄寸充ㄧ棰锛濡椋ㄩぇ锛娆℃板锛ュ悍瀹崇灏卞ぇ锛涔锛椋╁浣澶锛褰卞绱や椋╋杩勾榫浣浼澧绛澶涓奖绱

姝わ涓借浜寸椋╁氨涓瀹浼寰锛寤鸿灏介涓哄

1.<椋╀腑寸绱_姊.pdf>.

2.Habermeyer, M., et al., Nitrate and nitrite in the diet: how toassess their benefit and risk for human health. Mol Nutr Food Res, 2015. 59(1): p. 106-28.

3.Xu, L., et al., Urinary levels of N-nitroso compounds in relation to risk of gastriccancer: findings from the shanghai cohort study. PLoS One, 2015. 10(2): p. e0117326.

4.White, A.J., et al., Exposure to multiple sources of polycyclic aromatichydrocarbons and breast cancer incidence. Environ Int, 2016. 89-90: p. 185-192.

5.Domingo, J.L. and M. Nadal, Human dietary exposure to polycyclicaromatic hydrocarbons: A review of the scientific literature. Food ChemToxicol, 2015. 86: p. 144-53.

6.Duan, X., et al., Dietary intake polycyclic aromatic hydrocarbons (PAHs) and associatedcancer risk in a cohort of Chinese urban adults: Inter- and intra-individualvariability. Chemosphere, 2016. 144:p. 2469-75.

7.<BriefCommunication.pdf>.

8.Sieri, S., et al., Dietary fat intake and development of specific breast cancer subtypes.J Natl Cancer Inst, 2014. 106(5).

9.<JNCIJ Natl Cancer Inst-2014-Memo to the Media-.pdf>.

10.Torre, L.A., et al., Global cancer statistics, 2012. CA Cancer J Clin, 2015. 65(2): p. 87-108.

11.Tomioka, K., et al., Risk of Lung Cancer in Workers Exposed to Benzidine and/orBeta-Naphthylamine: A Systematic Review and Meta-Analysis. J Epidemiol,2016.

12.Poulsen, H.E., H. Prieme, and S. Loft, Role of oxidative DNA damage in cancerinitiation and promotion. Eur J Cancer Prev, 1998. 7(1): p. 9-16.

13.Cheng, K.C., et al., 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causesG----T and A----C substitutions. J Biol Chem, 1992. 267(1): p. 166-72.

14.Dreyfuss, J.H., Thirdhand smoke identified as potent, enduring carcinogen. CACancer J Clin, 2010. 60(4): p.203-4.

浣eagle涓ㄥ浜ぇ瀛诲ㄥ娉涓涓纭澹绌剁

娆㈣虫敞灏卞诲锛浜瑙ｆ村璧璁